Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy and Safety of a Cosmetic Formulation Containing Arginine Glutamate in Patients with Burn Scars

Han Bi Kim
,
In Suk Kwak
,
Mi Sun Kim
ORCID logo ,
Ji Young Um
ORCID logo ,
So Yeon Lee
,
Bo Young Chung
ORCID logo ,
Chun Wook Park
ORCID logo ,
Jong Gu Won
,
Sang Wook Park
,
Nam Seo Son
,
Nae Gyu Kang
,
Hye One Kim
* ORCID logo
Version 1 : Received: 25 January 2024 / Approved: 25 January 2024 / Online: 25 January 2024 (16:40:37 CET)

How to cite: Kim, H.B.; Kwak, I.S.; Kim, M.S.; Um, J.Y.; Lee, S.Y.; Chung, B.Y.; Park, C.W.; Won, J.G.; Park, S.W.; Son, N.S.; Kang, N.G.; Kim, H.O. Efficacy and Safety of a Cosmetic Formulation Containing Arginine Glutamate in Patients with Burn Scars. Preprints 2024, 2024011866. https://doi.org/10.20944/preprints202401.1866.v1 Kim, H.B.; Kwak, I.S.; Kim, M.S.; Um, J.Y.; Lee, S.Y.; Chung, B.Y.; Park, C.W.; Won, J.G.; Park, S.W.; Son, N.S.; Kang, N.G.; Kim, H.O. Efficacy and Safety of a Cosmetic Formulation Containing Arginine Glutamate in Patients with Burn Scars. Preprints 2024, 2024011866. https://doi.org/10.20944/preprints202401.1866.v1

Abstract

Background: Patients with burn scars often suffer from a ‘vicious cycle’ in which their skin becomes dry and pruritus. This greatly reduces patients' quality of life, but there is no well-known mechanism yet, and the development of drugs for effective treatment is necessary. Objective: This study evaluated the efficacy and safety of cosmetic formulation containing arginine glutamate ion pair (named as RE:pair) on epidermal barrier function and reducing pruritus. Materials and Methods: A total of 20 patients [15 male and 5 female; average age 48.35 ± 13.13 years] participated in evaluating the effectiveness of using the RE:pair formula topically twice daily for up to 4 weeks after burn pruritus. Treatment efficacy was evaluated by Numerical Rating Scale (NRS) for itching and pain, transepidermal water loss (TEWL), skin hydration, Vancouver Scar Scale (VSS) evaluation, and the patient’s overall satisfaction. Results: This formula was well-tolerated, with significant relief of NRS for itching and pain score after 2nd weeks and 4th weeks of application (p < 0.05). The itching score was high in some patients, and overall, it decreased significantly after 4 weeks compared to before application. Also, the personal pain score decreased after 4th weeks. Overall TEWL showed 35 % improvement after 4th week, and 52 % improvement was confirmed in arms and 19 % in legs. The overall improvement effect of skin hydration was also 45 % (p = 0.0012), and the improvement effect was 40 % (p = 0.0371) in areas including arms and 54 % (p = 0.0313) in areas including legs. All patient satisfactory evaluations were "excellent". Conclusions: RE:pair formula was safe and effective in improving skin barrier and itch relief, and if further studies are conducted, it can be used as an excellent topical treatment for post-burn scar that strengthens the skin barrier.

Keywords

Arginine Glutamate; Post-burn scar; Post-burn pruritus; Skin barrier

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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