Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neuroplastic Changes in Adult Urogenital Sensation Induced by Neonatal Cystitis – A Review of Studies and Filling of Gaps

Version 1 : Received: 5 January 2024 / Approved: 5 January 2024 / Online: 8 January 2024 (13:44:40 CET)

How to cite: Ness, T.N.; DeWitte, C. Neuroplastic Changes in Adult Urogenital Sensation Induced by Neonatal Cystitis – A Review of Studies and Filling of Gaps. Preprints 2024, 2024010528. https://doi.org/10.20944/preprints202401.0528.v1 Ness, T.N.; DeWitte, C. Neuroplastic Changes in Adult Urogenital Sensation Induced by Neonatal Cystitis – A Review of Studies and Filling of Gaps. Preprints 2024, 2024010528. https://doi.org/10.20944/preprints202401.0528.v1

Abstract

Research studies related to neuroplastic changes that occur secondary to a bout of cystitis at a critical neonatal period of development in female rats (P14-16) are reviewed. They reveal that neonatal bladder inflammation (NBI) leads to an adult phenotype with many of the features of the human disorder, interstitial cystitis. Neurochemical, behavioral and neurophysiological differences between rats which experienced NBI and control animals are discussed and new data presented.

Keywords

interstitial cystitis; visceral pain; neonatal; urinary bladder

Subject

Biology and Life Sciences, Neuroscience and Neurology

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