Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Monitoring of Women with Anti-ro/La Antibodies in Germany – Status Quo and Intensified Monitoring Concepts

Ivonne Bedei
* ORCID logo ,
David Kniess
,
Corinna Keil
ORCID logo ,
Aline Wolter
,
Johanna Schenk
,
Ulrich Sachs
,
Roland Axt-Fliedner
Version 1 : Received: 3 January 2024 / Approved: 4 January 2024 / Online: 4 January 2024 (15:18:00 CET)

A peer-reviewed article of this Preprint also exists.

Bedei, I.A.; Kniess, D.; Keil, C.; Wolter, A.; Schenk, J.; Sachs, U.J.; Axt-Fliedner, R. Monitoring of Women with Anti-Ro/SSA and Anti-La/SSB Antibodies in Germany—Status Quo and Intensified Monitoring Concepts. J. Clin. Med. 2024, 13, 1142. Bedei, I.A.; Kniess, D.; Keil, C.; Wolter, A.; Schenk, J.; Sachs, U.J.; Axt-Fliedner, R. Monitoring of Women with Anti-Ro/SSA and Anti-La/SSB Antibodies in Germany—Status Quo and Intensified Monitoring Concepts. J. Clin. Med. 2024, 13, 1142.

Abstract

Fetuses of pregnant women affected by anti-Ro/anti La antibodies are at risk to develop complete atrioventricular heart block (CAVB) and other potentially life-threatening cardiac affections. CAVB can develop in less than 24 hours. Treatment with anti-inflammatory drugs and immuno-globulins (IVIG) can restore normal rhythm if applied in the transition period. Routine weekly echocardiography as often recommended will seldomly detect emergent AVB. Surveillance of these pregnancies is controversial. To obtain an overview of the current practice in Germany we have developed a web-based survey sent by the DEGUM (German Society of Ultrasound in Med-icine) to ultrasound specialists. Home-monitoring by hand-held Doppler is a promising new approach. With the intention to evaluate practicability, we instructed pregnant women at risk to use hand-held Doppler in the vulnerable period between 18-26 weeks at our university center.

Keywords

Rheumatic disease in pregnancy; Fetal atrioventricular block; Homemonitoring; anti-Ro/anti-La antibodies; Lupus erythematodes; Sjögren Syndrom

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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