Version 1
: Received: 28 December 2023 / Approved: 29 December 2023 / Online: 29 December 2023 (11:31:53 CET)
How to cite:
Ajose, D.J.; Montso, P.K.; Ateba, C.N.; Saeed, S.I. Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers. Preprints2023, 2023122252. https://doi.org/10.20944/preprints202312.2252.v1
Ajose, D.J.; Montso, P.K.; Ateba, C.N.; Saeed, S.I. Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers. Preprints 2023, 2023122252. https://doi.org/10.20944/preprints202312.2252.v1
Ajose, D.J.; Montso, P.K.; Ateba, C.N.; Saeed, S.I. Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers. Preprints2023, 2023122252. https://doi.org/10.20944/preprints202312.2252.v1
APA Style
Ajose, D.J., Montso, P.K., Ateba, C.N., & Saeed, S.I. (2023). Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers. Preprints. https://doi.org/10.20944/preprints202312.2252.v1
Chicago/Turabian Style
Ajose, D.J., Collins Njie Ateba and Shamsaldeen Ibrahim Saeed. 2023 "Combating Antibiotic Resistance in a One Health Context: A Plethora of Frontiers" Preprints. https://doi.org/10.20944/preprints202312.2252.v1
Abstract
Abstract: One of the most significant medical advancements of the 20th century was the discovery of antibiotics, which continue to play a vital tool in the treatment and prevention of diseases in humans and animals. However, the imprudent use of antibiotics in all fields of One-Health and concerns about antibiotic resistance among bacterial pathogens have raised interest in antibiotic use restrictions on a global scale. Despite the failure of conventional antimicrobial agents, only about 15 new antibiotics have been introduced clinically since year 2000 to date. Moreover, there have been reports of resistance to some of these new antibiotics. This has necessitated a need to search for an alternative strategy to combat antimicrobial resistant pathogens. Thus, this review compiles and evaluates the approaches—natural compounds, phage treatment, and nanomaterials—that are being used and/or suggested as the potential substitutes for conventional antibiotics. These strategies include those that focus on the enzymes or proteins, as well as the physiology and metabolism of resistant bacteria
Keywords
Alternative therapy; antimicrobial resistance; natural product/compound; One-Health; secondary metabolite
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
