Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation

Zena Saleh
,
Matthew Christopher Moccia
ORCID logo ,
Zachary Ladd
,
Joneja Upasana
,
Yahui Li
,
Francis Spitz
,
Young Ki Hong
* ,
Tao Gao
*
Version 1 : Received: 22 December 2023 / Approved: 22 December 2023 / Online: 25 December 2023 (11:21:55 CET)

A peer-reviewed article of this Preprint also exists.

Saleh, Z.; Moccia, M.C.; Ladd, Z.; Joneja, U.; Li, Y.; Spitz, F.; Hong, Y.K.; Gao, T. Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation. Int. J. Mol. Sci. 2024, 25, 1331. Saleh, Z.; Moccia, M.C.; Ladd, Z.; Joneja, U.; Li, Y.; Spitz, F.; Hong, Y.K.; Gao, T. Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation. Int. J. Mol. Sci. 2024, 25, 1331.

Abstract

Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in treatment of PNETs at advanced stage. Epigenetic alterations profoundly impact the activity of signaling pathways in cancer development, offering potential opportunities for drug development. There is currently a lack of extensive research on epigenetic regulation in PNETs. To fill this gap, we first summarize major signaling events which are involved in PNET development. Then, we discuss the epigenetic regulation of these signaling pathways in the context of both PNET and commonly occurring, and therefore more extensively studied, malignancies. Finally, we will offer perspective on the future research direction of PNET epigenome and its potential applications in patient care.

Keywords

Pancreatic neuroendocrine tumors; signaling pathways; epigenetic regulation

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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