Version 1
: Received: 18 December 2023 / Approved: 18 December 2023 / Online: 19 December 2023 (09:40:28 CET)
How to cite:
Khedri, A.; Guo, S.; Ramar, V.; Hudson, B.; Liu, M. FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review. Preprints2023, 2023121378. https://doi.org/10.20944/preprints202312.1378.v1
Khedri, A.; Guo, S.; Ramar, V.; Hudson, B.; Liu, M. FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review. Preprints 2023, 2023121378. https://doi.org/10.20944/preprints202312.1378.v1
Khedri, A.; Guo, S.; Ramar, V.; Hudson, B.; Liu, M. FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review. Preprints2023, 2023121378. https://doi.org/10.20944/preprints202312.1378.v1
APA Style
Khedri, A., Guo, S., Ramar, V., Hudson, B., & Liu, M. (2023). FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review. Preprints. https://doi.org/10.20944/preprints202312.1378.v1
Chicago/Turabian Style
Khedri, A., BreAnna Hudson and Mingli Liu. 2023 "FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review" Preprints. https://doi.org/10.20944/preprints202312.1378.v1
Abstract
This review centers on the pivotal role of the oncoprotein FOSL1, within the dimeric AP-1 transcription factor consisting of FOS-related elements. FOSL1 emerges as a key regulator governing invasion and metastatic dissemination, therefore making it a promising target for therapeutic intervention in cancer patients. The review provides a comprehensive survey of the regulatory mechanisms that exert influence over FOSL1. These encompass a spectrum of transcriptional and post-translational modifications. Notably, we unveiled the intricate involvement of diverse non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in the modulation of FOSL1 expression through targeted interactions with its mRNA transcripts. Furthermore, an exploration into the functional dimensions of FOSL1 unfolds, encompassing apoptosis, proliferation, and migration. This investigation is accompanied by a thorough examination of the elaborate signaling pathways that underpin these multifaced roles. Additionally, emphasis is placed on the role of FOSL1 in orchestrating the stimulation of various cytokines, including TGF-beta, and the initiation of IL-6 and VEGF production in tumor-associated macrophages (TAMs) that transverse into the tumor microenvironment. A distinct focus is dedicated to appraising the prognostic implications associated with FOSL1. Finally, insights emerge into the evolving roles of FOSL1 in the context of mechanisms governing resistance and dependency on targeted therapeutic modalities.
Keywords
glioblastoma; FOSL1; glioma stem cells; drug resistance; prognosis; biomarker
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
