Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Prognostic Role of Global Longitudinal Strain and NT-proBNP in Heart Failure Patients Receiving Cardiac Resynchronization Therapy

Nikolaos PE Kadoglou
* ORCID logo ,
Sjoerd Bouwmeester
,
Anouk GW De Lepper
,
Marloes De Kleijn
,
Ingeborg HF Herold
,
Arthur Bouwman
,
Ioannis Korakianitis
,
Tim Simmers
,
Frank ALE Bracke
,
Patrick Houthuizen
Version 1 : Received: 13 December 2023 / Approved: 13 December 2023 / Online: 13 December 2023 (11:00:01 CET)

A peer-reviewed article of this Preprint also exists.

Kadoglou, N.P.E.; Bouwmeester, S.; de Lepper, A.G.W.; de Kleijn, M.C.; Herold, I.H.F.; Bouwman, A.R.A.; Korakianitis, I.; Simmers, T.; Bracke, F.A.L.E.; Houthuizen, P. The Prognostic Role of Global Longitudinal Strain and NT-proBNP in Heart Failure Patients Receiving Cardiac Resynchronization Therapy. J. Pers. Med. 2024, 14, 188. Kadoglou, N.P.E.; Bouwmeester, S.; de Lepper, A.G.W.; de Kleijn, M.C.; Herold, I.H.F.; Bouwman, A.R.A.; Korakianitis, I.; Simmers, T.; Bracke, F.A.L.E.; Houthuizen, P. The Prognostic Role of Global Longitudinal Strain and NT-proBNP in Heart Failure Patients Receiving Cardiac Resynchronization Therapy. J. Pers. Med. 2024, 14, 188.

Abstract

Background: We aimed to evaluate whether baseline GLS and NT-proBNP and their changes after cardiac resynchronization therapy (CRT) can predict the long-term clinical outcomes and the echocardiographic-based response to CRT (defined by 15% relative reduction in left ventricular end-systolic volume). Methods: We enrolled 143 patients with stable, ischemic heart failure (HF) undergoing CRT-D implantation. NT-proBNP and echocardiogram were obtained before and 6 months after. The patients were followed-up (median: 58 months) for HF-related deaths and/or HF hospitalizations (primary endpoint) or HF-related deaths (secondary endpoint) Results: 84 patients achieved the primary and 53 the secondary endpoint, while 104 patients were considered as CRT-responders and 39 as non-responders. At baseline, event-free patients had higher absolute GLS values (p<0.001) and lower NT-proBNP serum levels (p<0001) than those achieving primary endpoint. A similar pattern was observed in favor of CRT-responders vs non-responders. In Cox regression analysis, lower baseline absolute GLS value (HR=0.77;95%CI, 0.51-1.91; p=0.002), higher baseline NT-proBNP levels (HR=1.55;95%CI, 1.43-2.01;p=0.002) and diabetes (HR=1.27;95%CI, 1.12-1.98;p=0.003) were associated with lower incidence of primary endpoint. Conclusions: In HF patients undergoing CRT-D, baseline GLS and NT-proBNP concentrations may serve as prognostic factors, while they may predict the echocardiographic-based response to CRT.

Keywords

cardiac resynchronization therapy-CRT; global longitudinal strain-GLS; natriuretic peptides; heart failure

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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