Review
Version 1
Preserved in Portico This version is not peer-reviewed
Targeting the Metabolic Paradigms in Cancer and Diabetes
Version 1
: Received: 12 December 2023 / Approved: 13 December 2023 / Online: 13 December 2023 (03:26:13 CET)
A peer-reviewed article of this Preprint also exists.
Bosso, M.; Haddad, D.; Al Madhoun, A.; Al-Mulla, F. Targeting the Metabolic Paradigms in Cancer and Diabetes. Biomedicines 2024, 12, 211. Bosso, M.; Haddad, D.; Al Madhoun, A.; Al-Mulla, F. Targeting the Metabolic Paradigms in Cancer and Diabetes. Biomedicines 2024, 12, 211.
Abstract
As yin and yang, cancer and diabetes are metabolic disorders characterized by deregulated, yet opposing, metabolic alterations. These metabolic shifts reflect a complex network of defective underlying signaling pathways, which ultimately orchestrate both disease pathogenesis and progression. The Warburg effect portrays the chief metabolic phenotype in cancer and is reflected by the dominance of aerobic glycolysis over minimal-to-no viable oxidative phosphorylation in cancer. Conversely, during the pathogenesis of type 2 diabetes (T2D), oxidative phosphorylation is constantly heightened. In advanced insulin resistance and T2D, the metabolic landscape becomes more complex, with exacerbating metabolic alterations affecting oxidative phosphorylation in a tissue-specific manner. Promising nutritional adjuvants, such as alpha-lipoic acid and flavonoids, can reprogram metabolism and exert antitumor and antidiabetic effects. Other pharmacological agents, such as metformin, have therapeutic effects on cancer and T2D. Herein, we discuss the molecular mechanisms and signaling pathways involved in the metabolic shifts in cancer and T2D, and explore the therapeutic strategies under investigation that aim to reverse the metabolic shift in both disease scenarios.
Keywords
oxidative phosphorylation; cancer; mitochondria; metabolic shift; type 2 diabetes; insulin resistance; therapy; nutritional adjuvants; glutaminolysis
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
