Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Overview of Parenteral Nutrition from Birth to Adolescence, Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution

Version 1 : Received: 8 December 2023 / Approved: 8 December 2023 / Online: 8 December 2023 (15:19:06 CET)

A peer-reviewed article of this Preprint also exists.

Goulet, O. An Overview of Parenteral Nutrition from Birth to Adolescence Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution. Nutrients 2024, 16, 440. Goulet, O. An Overview of Parenteral Nutrition from Birth to Adolescence Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution. Nutrients 2024, 16, 440.

Abstract

Intestinal failure (IF) is characterized by a critical reduction of functional gut mass below the minimum needed for optimal growth in children. It requires parenteral nutrition (PN) and home-PN (HPN) which is challenging in terms of meeting nutritional needs according to age, growth velocity, clinical situation, and rapid changes in fluid and electrolyte requirements. Due to these complex requirements, age-adapted multi-chamber bags (MCBs) are important additions to the nutrition armamentarium. The launch of composite fish oil (FO)-containing intravenous lipid emulsions (ILEs) heralded the development of MCBs containing these ILEs in combination with a crystalline amino acids solution (CAAS) adapted for pediatric use. The safety and efficacy of lipid and amino acid components in this context have been widely documented in numerous published studies. This manuscript includes a review of the articles published in PubMed, Embase, and Google Scholar until June 2022, exploring studies in the age groups from term infants to children and adolescents. Preterm infants with their highly specific demands are not included. It aims to offer an overview of the clinical experience regarding the use of a composite FO-based ILE and a specific CAAS developed

Keywords

intestinal failure, parenteral nutrition, home parenteral nutrition, fish oil based intravenous lipid emulsion, crystalline amino acids solution, multi-chamber bags

Subject

Medicine and Pharmacology, Clinical Medicine

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