Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Efficacy and Metabolomics Modifications Induced by Polyphenol Compound Supplementation in the Treatment of Residual Dizziness Following Repositioning Maneuvers in Benign Paroxysmal Positional Vertigo (BPPV)

Augusto Pietro Casani
* ORCID logo ,
Roberto Albera
,
Cristina Piras
ORCID logo ,
Andrea Albera
ORCID logo ,
Antonio Noto
ORCID logo ,
Nicola Ducci
,
Luigi Atzori
ORCID logo ,
Sergio Lucisano
,
Michele Mussap
ORCID logo ,
Vassilios Fanos
Version 1 : Received: 21 November 2023 / Approved: 22 November 2023 / Online: 22 November 2023 (14:35:38 CET)

A peer-reviewed article of this Preprint also exists.

Casani, A.P.; Albera, R.; Piras, C.; Albera, A.; Noto, A.; Ducci, N.; Atzori, L.; Lucisano, S.; Mussap, M.; Fanos, V. Clinical Efficacy and Metabolomics Modifications Induced by Polyphenol Compound Supplementation in the Treatment of Residual Dizziness following Semont Maneuver in Benign Paroxysmal Positional Vertigo (BPPV) of the Posterior Semicircular Canal (PSC): Preliminary Results. Metabolites 2024, 14, 86. Casani, A.P.; Albera, R.; Piras, C.; Albera, A.; Noto, A.; Ducci, N.; Atzori, L.; Lucisano, S.; Mussap, M.; Fanos, V. Clinical Efficacy and Metabolomics Modifications Induced by Polyphenol Compound Supplementation in the Treatment of Residual Dizziness following Semont Maneuver in Benign Paroxysmal Positional Vertigo (BPPV) of the Posterior Semicircular Canal (PSC): Preliminary Results. Metabolites 2024, 14, 86.

Abstract

Benign Paroxysmal Positional Vertigo (BPPV) represents the most frequent cause of peripheral vertigo. In most cases it is successfully treated by canalith repositioning procedure (CRP), but it is often followed by a continuous lightheadedness in absence of vertigo or nystagmus (residual dizziness, RD). Our aim is to describe the clinical effectiveness and the urine metabolomics profile treating these patients by a polyphenol compound supplementation. We enrolled 30 patients reporting RD after BPPV successfully treated using CRP. A supplementation with a Polyphenol compound was administered for 60 days, and patients were evaluated after 30 and 60 days of treatment by a self-administered questionnaires (Visual Analog Scales for Dizziness and Nausea, Dizziness Handicap Inventory, DHI) and by urine metabolomics analysis performed by 1H-NMR spectroscopy and multivariate followed by univariate analysis. Most patients reported an excellent or good efficacy of RD with a significant decrease for VAS and DHI values. The metabolomics analysis identified six significant metabolites related to the treatment: 1-methylnicotinamide, anserine, Hippurate, lysine, methyl succinate, and urea indicating an inflammatory activities and antioxidant properties of the polyphenol compound. These preliminary data suggest that supplementation with a polyphenol compound cold induces some metabolic changes that can help recover RD. However, the future steps will require confirmation with a more significant cohort of patients and an extension of the metabolomic evaluation to other problems concerning the different clinical aspects of BPPV, such as the high relapse found in a high percentage of patients.

Keywords

metabolomics; metabolites; precision medicine; laboratory medicine; residual dizziness; benign paroxysmal positional vertigo; vertigo

Subject

Medicine and Pharmacology, Otolaryngology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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