Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano; Michele Di Mauro; Laura Labate; Alessandro Della Corte; Federica Lo Presti; Michele De Bonis; Cinzia Trumello; Mauro Rinaldi; Erik Cura Stura; Guglielmo Actis Dato; Giuseppe Punta; Francesco Nicolini; Davide Carino; Carlo De Vincentiis; Andrea Garatti; Giangiuseppe Cappabianca; Andrea M Musazzi; Diego Cugola; Maurizio Merlo; Davide Pacini; Gianluca Folesani; Sandro Sponga; Igor Vendramin; Alberto Pilozzi Casado; Francesco Rosato; Elisa Mikus; Carlo Savini; Francesco Onorati; Giovanni Battista Luciani; Roberto Scrofani; Francesco Epifani; Francesco Musumeci; Antonio Lio; Andrea Colli; Giosuè Falcetta; Salvatore Nicolardi; Salvatore Zaccaria; Enrico Vizzardi; Antonio Pantaleo; Giuseppe Minniti; Emmanuel Villa; Margherita Dalla Tomba; Francesco Pollari; Fabio Barili; Alessandro Parolari; Roberto Lorusso; Francesco Santini

doi:10.20944/preprints202311.0661.v1

A peer-reviewed article of this Preprint also exists.

Salsano, A.; Di Mauro, M.; Labate, L.; Della Corte, A.; Lo Presti, F.; De Bonis, M.; Trumello, C.; Rinaldi, M.; Cura Stura, E.; Actis Dato, G.; Punta, G.; Nicolini, F.; Carino, D.; De Vincentiis, C.; Garatti, A.; Cappabianca, G.; Musazzi, A.; Cugola, D.; Merlo, M.; Pacini, D.; Folesani, G.; Sponga, S.; Vendramin, I.; Pilozzi Casado, A.; Rosato, F.; Mikus, E.; Savini, C.; Onorati, F.; Luciani, G.B.; Scrofani, R.; Epifani, F.; Musumeci, F.; Lio, A.; Colli, A.; Falcetta, G.; Nicolardi, S.; Zaccaria, S.; Vizzardi, E.; Pantaleo, A.; Minniti, G.; Villa, E.; Dalla Tomba, M.; Pollari, F.; Barili, F.; Parolari, A.; Lorusso, R.; Santini, F. Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry. J. Clin. Med. 2024, 13, 153. Salsano, A.; Di Mauro, M.; Labate, L.; Della Corte, A.; Lo Presti, F.; De Bonis, M.; Trumello, C.; Rinaldi, M.; Cura Stura, E.; Actis Dato, G.; Punta, G.; Nicolini, F.; Carino, D.; De Vincentiis, C.; Garatti, A.; Cappabianca, G.; Musazzi, A.; Cugola, D.; Merlo, M.; Pacini, D.; Folesani, G.; Sponga, S.; Vendramin, I.; Pilozzi Casado, A.; Rosato, F.; Mikus, E.; Savini, C.; Onorati, F.; Luciani, G.B.; Scrofani, R.; Epifani, F.; Musumeci, F.; Lio, A.; Colli, A.; Falcetta, G.; Nicolardi, S.; Zaccaria, S.; Vizzardi, E.; Pantaleo, A.; Minniti, G.; Villa, E.; Dalla Tomba, M.; Pollari, F.; Barili, F.; Parolari, A.; Lorusso, R.; Santini, F. Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry. J. Clin. Med. 2024, 13, 153.

Abstract

Background: Infective endocarditis(IE) is a serious disease and in many cases surgery is necessary. Whether the type of prosthesis implanted for aortic valve replacement(AVR) for IE impacts patient survival is a matter of debate. The aim of the present study is to quantify differences in long-term survival, recurrence of endocarditis AVR for IE according to prosthesis type among patients aged 40 to 65 years. Methods: This was an analysis of the INFECT-REGISTRY. Overall, 4365 patients were diagnosed and operated on for IE from 2000 to 2021. Of these, 549 aged between 40 and 65 years underwent AVR. 268(48.8%) received mechanical prostheses, and 281(51.2%) biological ones. Confounders were adjusted using optimal full matching propensity score. Results: A significant trend in reduction of implantation of mechanical vs biological prostheses was observed during the study period(p<0.0001). Long-term survival was significantly higher among patients receiving a mechanical prosthesis than those receiving a biological prosthesis (hazard ratio [HR] 0.546,95%CI: 0.322-0.926, p=0.025). Mechanical prostheses were significantly associated with less recurrent endocarditis after AVR (HR 0.268,95%CI:0.077-0.933,p=0.039).Conclusions: The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after mechanical aortic valve prosthesis implant for IE in middle-aged patients.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

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