Pandit, V.; DeGeorge, K.; Nohe, A. Scoping Pleiotropy of CK2 in Musculoskeletal Disorders for a Novel Targeting Approach. Kinases Phosphatases2024, 2, 43-66.
Pandit, V.; DeGeorge, K.; Nohe, A. Scoping Pleiotropy of CK2 in Musculoskeletal Disorders for a Novel Targeting Approach. Kinases Phosphatases 2024, 2, 43-66.
Pandit, V.; DeGeorge, K.; Nohe, A. Scoping Pleiotropy of CK2 in Musculoskeletal Disorders for a Novel Targeting Approach. Kinases Phosphatases2024, 2, 43-66.
Pandit, V.; DeGeorge, K.; Nohe, A. Scoping Pleiotropy of CK2 in Musculoskeletal Disorders for a Novel Targeting Approach. Kinases Phosphatases 2024, 2, 43-66.
Abstract
Casein Kinase ІІ (CK2) is one of the most versatile kinases. Its involvement in almost all cellular pathways makes it the Master Regulator of biochemical processes in a cell. This kinase is essential in regulating inflammation, cell differentiation, and cell cycle regulation. Often simultaneously. Its emerging role in senescence also indicates its function's centrality in cellular metabolism. The strategy to target this kinase to treat musculoskeletal disorders seems effective. These disorders often include a component of inflammation, dysregulated cell differentiation, and aging. This review focuses on CK2 target discovery and the diversity of its substrate interactions. We then transition toward the implication of CK2 in musculoskeletal disorders. Through a summary of current strategies for CK2 targeting with a new approach, we discuss the potential aspects that could be addressed in future drug research.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
