Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract

Matteo Micucci Micucci; Anna Bartoletti-Stella; Fuad Othman Abdullah; Sabrina Burattini; Ilaria Versari; Matteo Canale; Federico D'Agostino; Davide Roncarati; Diletta Piatti; Gianni Sagratini; Giovanni Caprioli; Irene Faenza; Michela Battistelli; Sara Salucci

doi:10.20944/preprints202310.1328.v1

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preprints.org > medicine and pharmacology > complementary and alternative medicine > doi: 10.20944/preprints202310.1328.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract

Matteo Micucci Micucci

Anna Bartoletti-Stella

^* ,

Version 1 : Received: 19 October 2023 / Approved: 19 October 2023 / Online: 20 October 2023 (09:25:15 CEST)

A peer-reviewed article of this Preprint also exists.

Micucci, M.; Stella Bartoletti, A.; Abdullah, F.O.; Burattini, S.; Versari, I.; Canale, M.; D’Agostino, F.; Roncarati, D.; Piatti, D.; Sagratini, G.; Caprioli, G.; Mari, M.; Retini, M.; Faenza, I.; Battistelli, M.; Salucci, S. Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract. Int. J. Mol. Sci. 2023, 24, 16003. Micucci, M.; Stella Bartoletti, A.; Abdullah, F.O.; Burattini, S.; Versari, I.; Canale, M.; D’Agostino, F.; Roncarati, D.; Piatti, D.; Sagratini, G.; Caprioli, G.; Mari, M.; Retini, M.; Faenza, I.; Battistelli, M.; Salucci, S. Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract. Int. J. Mol. Sci. 2023, 24, 16003.

Abstract

Abstract Background: Gastric cancer, particularly adenocarcinoma, is a significant global health concern. Environmental risk factors, such as Helicobacter pylori infection and diet, play a role in its development. Purpose: This study aimed to characterize the chemical composition and evaluate the in vitro antibacterial and antitumor activities of AOME. Additionally, morphological changes in gastric cancer cell lines were analyzed. Study design: AOME was analyzed using HPLC-MS/MS and its antibacterial activity against H. pylori was assessed using the broth microdilution method. MIC and MBC values were determined, and positive and negative controls were included in the evaluation. Methods: Anticancer effects were assessed through in vitro experiments using AGS, KATO-III, and SNU-1 cancer cell lines. The morphological changes were examined through SEM and TEM analyses. Results: AOME contained several compounds, including caffeic acid, rutin, and hyperoside. The extract displayed significant antimicrobial effects against H. pylori, with consistent MIC and MBC values of 3.70 ± 0.09 mg/mL. AOME reduced cell viability in all gastric cancer cell in a dose and time-dependent manner. Morphological analyses revealed significant ultrastructural changes in all tumor cells lines, suggesting the occurrence of cellular apoptosis. Conclusions: This study demonstrated that AOME possesses antimicrobial activity against H. pylori and potent antineoplastic properties in gastric cancer cell lines. AOME holds promise as a natural resource for innovative nutraceutical approaches in gastric cancer management. Further research and in vivo studies are warranted to validate its potential clinical applications.

Keywords

gastric cancer prevention; nutraceuticals; phytochemicals; helicobacter pylori; aristolochia olivieri; apoptosis

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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