Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Optimal Lymphadenectomy in Patients with Nonfunctioning Pancreatic Neuroendocrine Neoplasms

Ryuta Shintakuya
,
Kenichiro Uemura
* ORCID logo ,
Tatsuaki Sumiyoshi
,
Kenjiro Okada
,
Kenta Baba
,
Takumi Harada
* ,
Yoshiaki Murakami
,
Masahiro Serikawa
ORCID logo ,
Yasutaka Ishii
ORCID logo ,
Koji Arihiro
,
Shinya Takahashi
Version 1 : Received: 9 October 2023 / Approved: 10 October 2023 / Online: 10 October 2023 (10:04:06 CEST)

A peer-reviewed article of this Preprint also exists.

Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med. 2023, 12, 6778. Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med. 2023, 12, 6778.

Abstract

This study aimed to evaluate the optimal extent of lymphadenectomy in patients with nonfunctioning pancreatic neuroendocrine neoplasms. We retrospectively analyzed the clinicopathological data of patients with nonfunctioning pancreatic neuroendocrine neoplasms who underwent surgical resection. We investigated the frequency of metastases at each lymph node station according to tumor location and analyzed the factors contributing to poor overall survival (OS) and disease-free survival (DFS). Overall, data of 84 patients were analyzed. For pancreatic head tumors, metastases at stations 8, 13, and 17 were found in one (3.1%), four (12.5%), and three (9.3%) patients, respectively. However, none of the other stations showed metastases. For pancreatic body and tail tumors, only metastases at station 11 were found in two (5.1%) patients. Additionally, multivariate DFS and OS analyses showed that lymph node metastasis was the only independent prognostic factor. Lymph node metastasis was found near the primary tumor and was the only independent factor of poor prognosis in patients with nonfunctioning pancreatic neuroendocrine neoplasms after undergoing curative surgery. Peri-pancreatic lymphadenectomy might be recommended for nonfunctioning pancreatic neuroendocrine neoplasms.

Keywords

lymph node dissection; nonfunctioning pancreatic neuroendocrine neoplasms; surgical resection

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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