Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Evolution of Robin Sequence Treatment based on the Biomimetic Interdisciplinary Approach: A Historical Review

Version 1 : Received: 6 October 2023 / Approved: 7 October 2023 / Online: 8 October 2023 (07:21:52 CEST)

A peer-reviewed article of this Preprint also exists.

Čverha, M.; Varga, I.; Trenčanská, T.; Šufliarsky, B.; Thurzo, A. The Evolution of Robin Sequence Treatment Based on the Biomimetic Interdisciplinary Approach: A Historical Review. Biomimetics 2023, 8, 536. Čverha, M.; Varga, I.; Trenčanská, T.; Šufliarsky, B.; Thurzo, A. The Evolution of Robin Sequence Treatment Based on the Biomimetic Interdisciplinary Approach: A Historical Review. Biomimetics 2023, 8, 536.

Abstract

Robin sequence is a congenital anomaly characterized by a triad of features that include micrognathia, glossoptosis, and airway obstruction. This comprehensive historical review maps the evolution of approaches and appliances for its treatment from the past until current modern possibilities of interdisciplinary combination of modern engineering, medicine, materials, and computer science combined approach with emphasis to design appliances inspired by nature - individual human anatomy. Current biomimetic designs are clinically applied resulting in appliances that are more efficient, comfortable, sustainable, and safer than legacy traditional designs. Review maps the treatment modalities that have been used for patients with Robin sequence over the years. Early management of Robin sequence focused primarily on airway maintenance and feeding support, while current management strategies involve both nonsurgical and surgical interventions and biomimetic biocompatible personalized appliances. The goal of this paper was to provide a review of the evolution of management strategies for patients with Robin sequence that led to the current interdisciplinary biomimetic approaches impacting the future of Robin Sequence treatment with biomimetics at the forefront.

Keywords

Pierre Robin Sequence; Micrognathia; Personalized; Appliance; Biocompatible; Glossoptosis; Regenerative dentistry; 3D printing

Subject

Medicine and Pharmacology, Clinical Medicine

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