Spatiotemporal distribution and molecular characterization of circulating dengue virus serotypes/genotypes in Senegal from 2019 to 2023

Idrissa Dieng; Cheikh Talla; Mamadou Aliou Barry; Aboubacry Gaye; Diamilatou Balde; Mignane Ndiaye; Mouhamed Kane; Samba Niang Sagne; Moussa Moïse DIAGNE; Boly Diop; Boubacar Diallo; Amadou Alpha Sall; Ousmane Faye; Abdourahmane Sow; Gamou Fall; Cheikh Loucoubar; Oumar Faye

doi:10.20944/preprints202310.0233.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202310.0233.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Spatiotemporal distribution and molecular characterization of circulating dengue virus serotypes/genotypes in Senegal from 2019 to 2023

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Version 1 : Received: 3 October 2023 / Approved: 9 October 2023 / Online: 9 October 2023 (10:08:42 CEST)

A peer-reviewed article of this Preprint also exists.

Dieng, I.; Talla, C.; Barry, M.A.; Gaye, A.; Balde, D.; Ndiaye, M.; Kane, M.; Sagne, S.N.; Diagne, M.M.; Diop, B.; et al. The Spatiotemporal Distribution and Molecular Characterization of Circulating Dengue Virus Serotypes/Genotypes in Senegal from 2019 to 2023. Tropical Medicine and Infectious Disease 2024, 9, 32, doi:10.3390/tropicalmed9020032. Dieng, I.; Talla, C.; Barry, M.A.; Gaye, A.; Balde, D.; Ndiaye, M.; Kane, M.; Sagne, S.N.; Diagne, M.M.; Diop, B.; et al. The Spatiotemporal Distribution and Molecular Characterization of Circulating Dengue Virus Serotypes/Genotypes in Senegal from 2019 to 2023. Tropical Medicine and Infectious Disease 2024, 9, 32, doi:10.3390/tropicalmed9020032.

Abstract

Dengue virus is becoming a major public health threat worldwide principally in Africa. From 2016 to 2020, 23 outbreaks were reported in Africa principally in West Africa. In Senegal outbreak are reported yearly since 2017 ; data about the circulating serotypes and their spatial and temporal distribution are limited to 2017 – 2018 period. Herein we describes up to date molecular surveillance of circulating DENV serotypes in Senegal between 2019 to 2023 and their temporal and spatial distribution around the country. For this purpose collected suspected DENV infections samples were subjected to dengue detection and serotyping using RT-qPCR methods. Positive samples subjected to temporal and spatial mapping. Subset of DENV+ samples were then sequenced and subjected to phylogenetic analysis. Results show a co-circulation of three DENV serotypes with a overall predominance of DENV-3 followed by DENV-1 with scarce cases of DENV-2 from 02_2019 to 02_2022. Interestingly data shows extinct of both serotype 1 and serotype 2 and the only circulation of DENV-3 from March 2022 to July 2023. At the genotype level analysis shows that sequenced strains belong to same genotype as previously described DENV-1 belong to genotype V, DENV-2 to cosmopolitan genotype and DENV-3 to Genotype III. Interestingly newly obtained DENV 1-3 sequences cluster in different clades within genotypes. This co-circulation of strains belonging to different clades could have effect on virus epidemiology and transmission dynamic. Overall our results highlight DENV serotypes replacement by DENV-3 accompanied by wider geographic distribution in Senegalese regions. All unmentioned results highlight the importance of virus genomic surveillance and call for further fitness studies using both in vitro and in vivo model as well as in depth phylogeographic study to uncover the virus dispersal patterns across the country.

Keywords

DENV; Serotypes; Senegal; Spatio-temporal distribution ; Genotypes

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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