Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Impact on Red Blood Cell Morphology

Kirill Kondratov
* ORCID logo ,
Alexander Artamonov
ORCID logo ,
Vladimir Mikhailovskii
ORCID logo ,
Anastasiya Velmiskina
,
Sergey Mosenko
ORCID logo ,
Evgeniy Grigoryev
ORCID logo ,
Anna Anisenkova
,
Yuri Nikitin
ORCID logo ,
Svetlana Apalko
,
Natalya Sushentseva
,
Andrey Ivanov
,
Sergey Shcherbak
Version 1 : Received: 3 October 2023 / Approved: 4 October 2023 / Online: 4 October 2023 (04:10:30 CEST)

A peer-reviewed article of this Preprint also exists.

Kondratov, K.A.; Artamonov, A.A.; Mikhailovskii, V.Y.; Velmiskina, A.A.; Mosenko, S.V.; Grigoryev, E.A.; Anisenkova, A.Y.; Nikitin, Y.V.; Apalko, S.V.; Sushentseva, N.N.; Ivanov, A.M.; Scherbak, S.G. SARS-CoV-2 Impact on Red Blood Cell Morphology. Biomedicines 2023, 11, 2902. Kondratov, K.A.; Artamonov, A.A.; Mikhailovskii, V.Y.; Velmiskina, A.A.; Mosenko, S.V.; Grigoryev, E.A.; Anisenkova, A.Y.; Nikitin, Y.V.; Apalko, S.V.; Sushentseva, N.N.; Ivanov, A.M.; Scherbak, S.G. SARS-CoV-2 Impact on Red Blood Cell Morphology. Biomedicines 2023, 11, 2902.

Abstract

Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The purpose of this research was to identify erythrocyte types that were unique to COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion. Red blood cells obtained from 6 control donors (800-2200 cells for each donor) and 5 COVID-19 patients (800-1900 cells for each patient) were examined using low voltage scanning electron microscopy. We did not discover any forms of poikilocytes that would be unique to COVID-19. Among COVID-19 patients, we observed an increase in the number of acanthocytes (p=0.01) and a decrease in the number of spherocytes (p=0.03). In addition, our research demonstrates that COVID-19 causes an increase in the median (p=0.004) and interquartile range (p=0.009) when assessing erythrocyte size.

Keywords

COVID-19; erythrocyte; red blood cells; cytokine storm; severe COVID-19; low voltage scanning electron microscopy; erythrocyte size

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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