Das, A.; Mehrotra, S.; Kumar, A. Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents. J. Funct. Biomater.2023, 14, 544.
Das, A.; Mehrotra, S.; Kumar, A. Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents. J. Funct. Biomater. 2023, 14, 544.
Das, A.; Mehrotra, S.; Kumar, A. Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents. J. Funct. Biomater.2023, 14, 544.
Das, A.; Mehrotra, S.; Kumar, A. Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents. J. Funct. Biomater. 2023, 14, 544.
Abstract
Coronary artery disease is the most prevalent cardiovascular disease, claiming millions of lives annually around the world. The current treatment includes surgically inserting a tubular construct called as a stent inside arteries to restore blood flow. However, due to lack of patient-specific design, the commercial products cannot be used with different vessel anatomies. In this review, we have summarized the drawbacks in existing commercial metal stents which face problems of restenosis and inflammatory responses, owing to the development of neointimal hyperplasia. Further, we have highlighted the fabrication of stents using biodegradable polymers, which can circumvent most of the existing limitations. In this regard, we elaborated on utilization of new fabrication methodologies based on additive manufacturing such as three-dimensional printing to design patient-specific stents. Finally, we have discussed on the functionalization of these stent surfaces with suitable bioactive molecules which can prove to enhance their properties in preventing thrombosis and better healing of injured blood vessel lining.
Keywords
atherosclerosis; coronary artery disease; stent; bio-resorbable; 3D printing
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
