Version 1
: Received: 24 September 2023 / Approved: 25 September 2023 / Online: 27 September 2023 (04:19:06 CEST)
How to cite:
Niazi, S.K.; Magoola, M. Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective. Preprints2023, 2023091793. https://doi.org/10.20944/preprints202309.1793.v1
Niazi, S.K.; Magoola, M. Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective. Preprints 2023, 2023091793. https://doi.org/10.20944/preprints202309.1793.v1
Niazi, S.K.; Magoola, M. Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective. Preprints2023, 2023091793. https://doi.org/10.20944/preprints202309.1793.v1
APA Style
Niazi, S.K., & Magoola, M. (2023). Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective. Preprints. https://doi.org/10.20944/preprints202309.1793.v1
Chicago/Turabian Style
Niazi, S.K. and Matthias Magoola. 2023 "Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective" Preprints. https://doi.org/10.20944/preprints202309.1793.v1
Abstract
Device-mediated, non-invasive drug delivery across the blood-brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It is a highly selective barrier, which poses a challenge to delivering therapeutic agents into the brain. Several non-invasive techniques and devices have been proposed or investigated to enhance drug delivery across the BBB. This paper presents the current state of the art and case studies that address the pharmacology, technology, delivery systems, regulatory approval, ethical concerns, and future possibilities.
Keywords
neurodegenerative disorders; blood-brain barrier; non-invasive delivery; device-related delivery; Alzheimer’s; Parkinson’s; ALS ; Down Syndrome
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
