Version 1
: Received: 12 September 2023 / Approved: 13 September 2023 / Online: 13 September 2023 (10:07:21 CEST)
How to cite:
Eralp, Y.; Ates, U. Clinical Applications of Combined İmmunotherapy Approaches in Gastrointestinal Cancer: A Case-Based Review. Preprints2023, 2023090860. https://doi.org/10.20944/preprints202309.0860.v1
Eralp, Y.; Ates, U. Clinical Applications of Combined İmmunotherapy Approaches in Gastrointestinal Cancer: A Case-Based Review. Preprints 2023, 2023090860. https://doi.org/10.20944/preprints202309.0860.v1
Eralp, Y.; Ates, U. Clinical Applications of Combined İmmunotherapy Approaches in Gastrointestinal Cancer: A Case-Based Review. Preprints2023, 2023090860. https://doi.org/10.20944/preprints202309.0860.v1
APA Style
Eralp, Y., & Ates, U. (2023). Clinical Applications of Combined İmmunotherapy Approaches in Gastrointestinal Cancer: A Case-Based Review. Preprints. https://doi.org/10.20944/preprints202309.0860.v1
Chicago/Turabian Style
Eralp, Y. and Utku Ates. 2023 "Clinical Applications of Combined İmmunotherapy Approaches in Gastrointestinal Cancer: A Case-Based Review" Preprints. https://doi.org/10.20944/preprints202309.0860.v1
Abstract
Malignant neoplasms arising from the gastrointestinal (GI) tract are among the most common cancer types with a high mortality rate. Despite advances in treatment in a small subgroup harboring targetable mutations, the outcome remains poor, accounting for one in three cancer-related deaths observed globally. As a promising therapeutic option in various tumor types, immunotherapy with immune checkpoint inhibitors has also been evaluated in GI cancer, albeit with limited efficacy except for a small subgroup expressing microsatellite instability. In the quest for more effective treatment options, energetic efforts have been placed to evaluate the role of several immunotherapy approaches comprising of cancer vaccines, adoptive cell therapies and immune checkpoint inhibitors. In this review, we report our experience with personalized dendritic cell cancer vaccine and cytokine-induced killer cell therapy in three patients with GI cancers and summarize current clinical data on combined immunotherapy strategies.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
