Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension

Edelvita Fernanda Duarte Cunha
,
Matheus Sobral Silveira
,
Juliana Cristina Milan-Mattos
* ,
Heitor Fernandes Silveira Cavalini
,
Ádrya Aryelle Ferreira
,
Joice de Souza Batista
,
Lara Cazé Uzumak
,
João Paulo Coelho Guimarães
,
Pedro Igor Lustosa Roriz
,
Fabianne Maisa de Novaes Assis Dantas
,
Arto J. Hautala
ORCID logo ,
Raphael Martins De Abreu
,
Aparecida Maria Catai
* ORCID logo ,
Paulo Adriano Schwingel
* ORCID logo ,
Victor Ribeiro Neves
* ORCID logo
Version 1 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (09:55:39 CEST)

A peer-reviewed article of this Preprint also exists.

Cunha, E.F.D.; Silveira, M.S.; Milan-Mattos, J.C.; Cavalini, H.F.S.; Ferreira, Á.A.; Batista, J.S.; Uzumaki, L.C.; Guimarães, J.P.C.; Roriz, P.I.L.; Dantas, F.M.N.A.; Hautala, A.J.; de Abreu, R.M.; Catai, A.M.; Schwingel, P.A.; Neves, V.R. Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension. J. Pers. Med. 2023, 13, 1391. Cunha, E.F.D.; Silveira, M.S.; Milan-Mattos, J.C.; Cavalini, H.F.S.; Ferreira, Á.A.; Batista, J.S.; Uzumaki, L.C.; Guimarães, J.P.C.; Roriz, P.I.L.; Dantas, F.M.N.A.; Hautala, A.J.; de Abreu, R.M.; Catai, A.M.; Schwingel, P.A.; Neves, V.R. Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension. J. Pers. Med. 2023, 13, 1391.

Abstract

Individuals diagnosed with systemic arterial hypertension (SAH) are considered risk groups for COVID-19 severity. This study assessed differences in cardiac autonomic function (CAF) and functional capacity (CF) in SAH individuals without COVID-19 infection compared to SAH individuals post-COVID-19. Participants comprised 40 SAH individuals aged 31 to 80 years old, grouped as SAH with COVID-19 (G1; n=21) and SAH without COVID-19 (G2; n=19). CAF was assessed via heart rate variability (HRV), measuring R-R intervals during a 10-minute supine period. Four HRV indices were analyzed through symbolic analysis: 0V%, 1V%, 2LV%, and 2UV%. FC assessment was performed by a 6-minute walk test (6MWT). G1 and G2 showed no difference between significant age, anthropometric, clinical and medication. G2 exhibited superior 6MWT performance, covering more distance (522±78 vs. 465±59 meters, p<0.05). Specifically, G2 demonstrated a moderate, positive correlation between 6MWT and the 2LV% index (r=0.58; p<0.05). Shorter walking distances were observed during 6MWT in SAH individuals post-COVID-19. However, the study did not find impaired cardiac autonomic function in SAH individuals post-COVID-19 compared to those without. This suggests that while COVID-19 impacted FC, CAF remained relatively stable in this population.

Keywords

hypertension; SARS-CoV-2; post-COVID conditions; physical functional performance; autonomic nervous system diseases; heart rate control.

Subject

Public Health and Healthcare, Physical Therapy, Sports Therapy and Rehabilitation

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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