Cancer Metabolism as a Therapeutic Target and Review of Interventions

Matthew TJ Halma; Jack A Tuszynski; Paul E Marik

doi:10.20944/preprints202308.2001.v2

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202308.2001.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Cancer Metabolism as a Therapeutic Target and Review of Interventions

Matthew TJ Halma

Jack A Tuszynski

Paul E Marik

Version 1 : Received: 28 August 2023 / Approved: 29 August 2023 / Online: 30 August 2023 (05:07:07 CEST)
Version 2 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (09:54:47 CEST)

A peer-reviewed article of this Preprint also exists.

Halma, M.T.J.; Tuszynski, J.A.; Marik, P.E. Cancer Metabolism as a Therapeutic Target and Review of Interventions. Nutrients 2023, 15, 4245. Halma, M.T.J.; Tuszynski, J.A.; Marik, P.E. Cancer Metabolism as a Therapeutic Target and Review of Interventions. Nutrients 2023, 15, 4245.

Abstract

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be effected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention, and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.

Keywords

warburg effect; cancer treatment; cancer metabolism; repurposed drugs

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 31 August 2023
Commenter: Matthew Halma
Commenter's Conflict of Interests: Author

Comment: The previous copy was an older copy with figures not reflecting the rest of the text, a major typo in the title, and an omitted author. These have been corrected.

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