Šanjug, J.; Kuna, K.; Goldštajn, M.Š.; Dunkić, L.F.; Carek, A.; Negovetić Vranić, D. Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour. J. Clin. Med.2023, 12, 6298.
Šanjug, J.; Kuna, K.; Goldštajn, M.Š.; Dunkić, L.F.; Carek, A.; Negovetić Vranić, D. Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour. J. Clin. Med. 2023, 12, 6298.
Šanjug, J.; Kuna, K.; Goldštajn, M.Š.; Dunkić, L.F.; Carek, A.; Negovetić Vranić, D. Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour. J. Clin. Med.2023, 12, 6298.
Šanjug, J.; Kuna, K.; Goldštajn, M.Š.; Dunkić, L.F.; Carek, A.; Negovetić Vranić, D. Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour. J. Clin. Med. 2023, 12, 6298.
Abstract
Background: The COMT gene polymorphism is associated with neurological and psychiatric disorders and pain perception. This study aimed to determine the relationship between the COMT (catechol-O-methyltransferase) gene polymorphism, pain perception in parturients with inhaled nitrous oxide during labour, and anxiety as a personality trait. Methods: A total number of 181 woman who chose vaginal birth were enrolled in this study. To present the difference in pain perception, the parturients were divided into one group (n=80) that chose labour analgesia with inhaled nitrous oxide (50% nitrous oxide and 50% oxygen) and one group without analgesia. The blood samples were taken during the pregnancy as a part of routine pregnancy controls in the hospital. The COMT gene polymorphism was detected with the PCR technique. Pain perception of labouring women was self-evaluated two times according to the VAS (Visual Analogue Scale) and anxiety as a personality trait was determined with STAI-T (State Trait Anxiety Inventory). Pain perception as well as anxiety were compared according to COMT genotypes. Results: In the 181 pregnant women there were 40 women (22%) of wild homozygotes (GG) of COMT, 95 women (53%) of mutant heterozygotes (GA), and 46 women (25%) of mutant homozygote (AA). A negative association of pain perception with the GA (mutant heterozigote) polymorphism of the COMT gene versus the wild type (GG polymorphism) was observed. The GA polymorphism of the COMT gene was associated with 0.46 units lower pain perception compared to the wild type (GG). The anxiety trait score in group AA was lower than in groups GA and AA. The difference reached statistical significance only when comparing AA versus GA (P>0.042). Analgesic efficacy of nitrous oxide was noticed in 22% of labouring women who reported moderate pain (VAS score 4-7). Conclusions: The COMT gene polymorphism was associated with pain perception and anxiety among labouring women. The COMT gene polymorphism GA was associated with negative pain perception among labouring women. Nitrous oxide showed statistical significance in anxiolytic efficacy during labour in women with mild anxiety as a personality trait. Anxiolytic efficacy of nitrous oxide has shown better efficacy in labouring women with the COMT gene polymorphism AA.
Medicine and Pharmacology, Obstetrics and Gynaecology
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