Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Albumin: A Biomarker to Be Repurposed

Elisa Gremese
* ORCID logo ,
Dario Bruno
ORCID logo ,
Valentina Varriano
,
Simone Perniola
ORCID logo ,
Luca Petricca
,
Gianfranco Ferraccioli
Version 1 : Received: 22 August 2023 / Approved: 22 August 2023 / Online: 23 August 2023 (09:14:44 CEST)

A peer-reviewed article of this Preprint also exists.

Gremese, E.; Bruno, D.; Varriano, V.; Perniola, S.; Petricca, L.; Ferraccioli, G. Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice. J. Clin. Med. 2023, 12, 6017. Gremese, E.; Bruno, D.; Varriano, V.; Perniola, S.; Petricca, L.; Ferraccioli, G. Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice. J. Clin. Med. 2023, 12, 6017.

Abstract

Serum albumin (ALB), one of the most important proteins in human physiology, has the main functions of maintaining plasma oncotic pressure and plasma volume, transporting hormones, vitamins, oligominerals and drugs, and exerting a powerful antioxidant-antiinflammatory role. Its prognostic value in liver and malabsorption syndromes is well known. In this narrative review, an analysis of the most important studies evaluating the prognostic significance of low serum ALB levels in hospitalized patients was performed. Specifically, the risk in emergency medicine, cardiovascular diseases, COVID-19 infection, nephrology, oncology and autoimmune rheumatic diseases has been examined to fully explore its clinical value. ALB is a negative acute-phase reactant and the reduction of its serum levels represents a threatening parameter for long-term survival in several clinical settings, and a strong poor prognostic biomarker in most diseases. Therefore, clinicians should consider serum ALB as a valuable tool to assess the efficacy of specific therapies, both in hospitalized patients and in chronic follow-up.

Keywords

Albumin levels; pre-Albumin levels; Emergency Department; Nephrology; Cardiology; Oncology; Infectious Diseases; Intensive Care Units; Rheumatologig Autoimmune Diseases.

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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