Palamar, M.; Grosu, I.; Schiller, A.; Petrica, L.; Bodea, M.; Sircuta, A.; Rusan, C.; Tanasescu, D.M.; Bob, F. Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study. Appl. Sci.2023, 13, 10938.
Palamar, M.; Grosu, I.; Schiller, A.; Petrica, L.; Bodea, M.; Sircuta, A.; Rusan, C.; Tanasescu, D.M.; Bob, F. Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study. Appl. Sci. 2023, 13, 10938.
Palamar, M.; Grosu, I.; Schiller, A.; Petrica, L.; Bodea, M.; Sircuta, A.; Rusan, C.; Tanasescu, D.M.; Bob, F. Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study. Appl. Sci.2023, 13, 10938.
Palamar, M.; Grosu, I.; Schiller, A.; Petrica, L.; Bodea, M.; Sircuta, A.; Rusan, C.; Tanasescu, D.M.; Bob, F. Vitamin K Status of Patients Undergoing Hemodialysis: Insights from a Cross-Sectional Study. Appl. Sci. 2023, 13, 10938.
Abstract
(1) Background: Vitamin K deficiency is a common feature of chronic kidney disease (CKD), leading to impaired bone quality and increased risk of vascular calcifications. A method to indirectly measure Vitamin K status is measuring the blood level of Vitamin K dependent proteins (VKDP)- osteocalcin (OC) and matrix GLA protein (MGP). The aim of this study is to correlate the level of OC and MGP with markers of CKD mineral bone disorder (CKD-MBD). (2) Methods: We conducted a single-center cross-sectional study that included 45 CKD G5D patients and measured blood biochemistry, complete blood count and intact osteocalcin and matrix GLA protein. (3) Results: We found a strong statistically significant correlation of OC with the markers of CKD-MBD such as: iPTH , serum calcium and serum phosphorus and a strong indirect statistically significant correlation with abdominal circumference. There was also a statistically significant correlation of MGP with markers of inflammation (CRP). Higher levels of MGP were found in patients treated with vitamin K antagonists, non-calcium based phosphate binders and vitamin D receptor activator- paricalcitol. (4) Conclusions: In our study, we found that vitamin K deficiency, measured indirectly using the level of VKDP is associated to CKD-MBD. The use of medication such as phosphate binders, that reduce vitamin K absorbtion, Vitamin D that increases Vitamin K requirements and also vitamin K antagonists, seem to have an influence on the blood level of VKDPs.
Keywords
hemodialysis, calcifications, vitamin K, osteocalcin, Matrix Gla protein
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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