Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Cariprazine in an Adolescent with Tourette Syndrome with Comorbid ADHD and Depression: A Case Report

Version 1 : Received: 14 August 2023 / Approved: 14 August 2023 / Online: 14 August 2023 (10:21:48 CEST)

A peer-reviewed article of this Preprint also exists.

Gill, J.S. Cariprazine in an Adolescent with Tourette syndrome with Comorbid Attention Deficit Hyperactive Disorder and Depression: A Case Report. Healthcare 2023, 11, 2531. Gill, J.S. Cariprazine in an Adolescent with Tourette syndrome with Comorbid Attention Deficit Hyperactive Disorder and Depression: A Case Report. Healthcare 2023, 11, 2531.

Abstract

Tourette syndrome is a complex neuropsychiatric condition that manifests in childhood and is often associated with other psychiatric comorbidities. This case describes a young male with Tourette syndrome with major depressive disorder and attention deficit hyperactivity disorder (ADHD), who experienced troublesome side-effects due to his existing medications (escitalopram, risperidone and methylphenidate). In order to control his tics, ameliorate depressive symptoms, and eliminate side-effects of stiffness and sedation, risperidone was switched to cariprazine, a third-generation antipsychotic medication with D3-D2 partial agonism. In addition, the antidepressant dose was also increased. With the new combination, the patient reported good control of his tics, together with significant improvement in depressive symptoms and no side-effects. Based on this case and the reviewed literature, cariprazine might be a viable option for patients with Tourette syndrome with other comorbid illnesses, whom are prone to side effects of medication.

Keywords

cariprazine; Tourette syndrome; major depressive disorder; ADHD; tics

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

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