Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Differences in Central and Peripheral Choroidal Thickness Among the Subtypes of Age-Related Macular Degeneration

Yosuke Fukuda
,
Shoji Notomi
* ORCID logo ,
Satomi Shiose
,
Kumiko Kano
,
Sawako Hashimoto
,
Kohta Fujiwara
,
Masato Akiyama
,
Keijiro Ishikawa
,
Toshio Hisatomi
,
Koh-Hei Sonoda
Version 1 : Received: 9 August 2023 / Approved: 10 August 2023 / Online: 10 August 2023 (05:34:57 CEST)

A peer-reviewed article of this Preprint also exists.

Fukuda, Y.; Notomi, S.; Shiose, S.; Kano, K.; Hashimoto, S.; Fujiwara, K.; Akiyama, M.; Ishikawa, K.; Hisatomi, T.; Sonoda, K.-H. Differences in Central and Peripheral Choroidal Thickness among the Subtypes of Age-Related Macular Degeneration in an Asian Population. J. Clin. Med. 2023, 12, 5364. Fukuda, Y.; Notomi, S.; Shiose, S.; Kano, K.; Hashimoto, S.; Fujiwara, K.; Akiyama, M.; Ishikawa, K.; Hisatomi, T.; Sonoda, K.-H. Differences in Central and Peripheral Choroidal Thickness among the Subtypes of Age-Related Macular Degeneration in an Asian Population. J. Clin. Med. 2023, 12, 5364.

Abstract

Age-related macular degeneration (AMD) causes visual impairment in individuals >50 years of age. However, no study has investigated AMD using ultra-wide-field swept-source optical co-herence tomography (UWF SS-OCT). We aimed to evaluate central and peripheral choroidal thickness using UWF SS-OCT and compare AMD subtypes. We included 75 eyes of patients with typical AMD (tAMD), 56 with polypoidal choroidal vasculopathy (PCV), 29 with pachychoroid neovasculopathy (PNV), and 12 with retinal angiomatous proliferation (RAP). To compare cho-roidal thicknesses in the central and peripheral choroids, we established subfields of <3 mm, <9 mm, and 9–18 mm from the fovea. PNV patients were significantly younger than those with tAMD (P=0.01). The choroidal thicknesses of PNV were significantly greater than that of tAMD in all subfields (P<0.01) and choroidal thickness significantly correlated with age and axial length in all subfields (P<0.05). Even after adjusting for age and axial length, the choroidal thickness in PNV was significantly greater than that in tAMD (P<0.05). In addition, the ratio of the posterior < 9 mm to peripheral 9–18 mm choroidal thickness in PNV was significantly greater than that in tAMD (P<0.01). A thickened choroid in PNV was more pronounced in the posterior choroid than in the periphery.

Keywords

age-related macular degeneration; pachychoroid spectrum disease; polypoidal choroidal vasculopathy; pachychoroid neovasculopathy; ultra-wide-field swept-source optical coherent tomography

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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