Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Pancreatic Cancer- Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

Anna Lisa Cammarota
* ORCID logo ,
Antonia Falco
,
Anna Basile
,
Carlo Molino
,
Massimiliano Chetta
ORCID logo ,
Gianni D'Angelo
ORCID logo ,
Liberato Marzullo
ORCID logo ,
Margot De Marco
* ORCID logo ,
Maria Caterina Turco
,
Alessandra Rosati
* ORCID logo
Version 1 : Received: 7 August 2023 / Approved: 7 August 2023 / Online: 7 August 2023 (12:12:00 CEST)

A peer-reviewed article of this Preprint also exists.

Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers 2023, 15, 4825. Cammarota, A.L.; Falco, A.; Basile, A.; Molino, C.; Chetta, M.; D’Angelo, G.; Marzullo, L.; De Marco, M.; Turco, M.C.; Rosati, A. Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment. Cancers 2023, 15, 4825.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a ravaging disease whose poor prognosis requires a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggested to rather focus on the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer secreted proteins in the complex TME tumor-stroma crosstalk, to sched lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.

Keywords

Pancreatic Ductal Adenocarcinoma; secretome; cell signaling; tumor microenvironment; small molecules; monoclonal antibodies.

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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