Antibody Response after 3 Dose Booster against SARS-CoV-2 mRNA Vaccine in Kidney Transplant Recipients

Domenico Tripodi; Roberto Dominici; Gennaro Santorelli; Rodolfo Rivera; Sandro Acquaviva; Marino Marchisio; Paolo Brambilla; Graziana Battini; Valerio Leoni

doi:10.20944/preprints202308.0056.v1

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preprints.org > medicine and pharmacology > immunology and allergy > doi: 10.20944/preprints202308.0056.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antibody Response after 3 Dose Booster against SARS-CoV-2 mRNA Vaccine in Kidney Transplant Recipients

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Version 1 : Received: 29 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (10:38:45 CEST)

A peer-reviewed article of this Preprint also exists.

Tripodi, D.; Dominici, R.; Sacco, D.; Santorelli, G.; Rivera, R.; Acquaviva, S.; Marchisio, M.; Brambilla, P.; Battini, G.; Leoni, V. Antibody Response after 3-Dose Booster against SARS-CoV-2 MRNA Vaccine in Kidney Transplant Recipients. Vaccines 2024, 12, 264, doi:10.3390/vaccines12030264. Tripodi, D.; Dominici, R.; Sacco, D.; Santorelli, G.; Rivera, R.; Acquaviva, S.; Marchisio, M.; Brambilla, P.; Battini, G.; Leoni, V. Antibody Response after 3-Dose Booster against SARS-CoV-2 MRNA Vaccine in Kidney Transplant Recipients. Vaccines 2024, 12, 264, doi:10.3390/vaccines12030264.

Abstract

The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in kidney transplant recipients (KTRs). The current vaccine strategy for KTRs seems to be unable to provide effective protection against coronavirus disease 2019 (COVID-19) [2] and the occurrence of severe COVID-19 in some vaccinated KTRs suggested a lack of immunity. We analized here the antibody response in a group of 32 kidney transplant recipients (KTR) followed at the Nephrology and Dialysis unit of the Hospital Pio XI of Desio, Italy, compared with a group of 23 healthy workers classified as Late responders (HCW-LR) (10 males age 27-62) and 13 females (age 46-64). We observed that the patients need additional vaccine boosters due to their immunocompromised status and therapy to protect them from infections related to viral variants, in accordance with the literature.

Keywords

Covid-19; antibody response; vaccination; kidney transplant recipients

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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