Preprint Brief Report Version 2 Preserved in Portico This version is not peer-reviewed

Kelleni’s Protocol Including NSAIDs and Nitazoxanide to Early Manage Dengue Virus Disease: A Novel Potential Broad Spectrum Antiviral Protocol

Version 1 : Received: 28 July 2023 / Approved: 31 July 2023 / Online: 31 July 2023 (11:40:48 CEST)
Version 2 : Received: 29 August 2023 / Approved: 30 August 2023 / Online: 30 August 2023 (07:30:36 CEST)

How to cite: Kelleni, M. Kelleni’s Protocol Including NSAIDs and Nitazoxanide to Early Manage Dengue Virus Disease: A Novel Potential Broad Spectrum Antiviral Protocol. Preprints 2023, 2023072079. https://doi.org/10.20944/preprints202307.2079.v2 Kelleni, M. Kelleni’s Protocol Including NSAIDs and Nitazoxanide to Early Manage Dengue Virus Disease: A Novel Potential Broad Spectrum Antiviral Protocol. Preprints 2023, 2023072079. https://doi.org/10.20944/preprints202307.2079.v2

Abstract

The current recommendation to avoid non-steroidal anti-inflammatory drugs (NSAIDs) in management of dengue virus disease is, as it was adopted earlier in COVID-19, scientifically considered of very low to low certainty. In this perspective I argue, for the first time globally, basing on real-life practice that NSAIDs might be lifesaving in early management of dengue virus disease as I originally argued and proved rightful in COVID-19. Moreover, I also argue that the Egyptian immune-modulatory Kelleni’s protocol, including nitazoxanide as an integral component, can be safely and effectively used to early manage COVID-19, human metapneumovirus, dengue virus disease, Zika virus separate or co-infections similar to what has already been experienced and published with separate or conjoined infections with SARS CoV-2, influenza, RSV and Norwalk viruses without the need of prior serological or molecular investigations to determine the causative agent.

Keywords

dengue virus disease; nitazoxanide; ibuprofen; NSAIDs; Kelleni’s protocol

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Comments (1)

Comment 1
Received: 30 August 2023
Commenter: Mina Kelleni
Commenter's Conflict of Interests: Author
Comment: The original version has been revised; some typos were corrected, additional discussion and references were added to include the current and potential viruses that are and could be managed using Kelleni's protocol and a figure was also inserted. 
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