Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Genome-wide Association Study and Identifying Candidate Genes for Intramuscular Fat Fatty Acid Compositions in Ningxiang Pigs

Qinghua Zeng
,
Hu Gao
ORCID logo ,
Shishu Yin
ORCID logo ,
Yinglin Peng
,
Fang Yang
,
Yawei Fu
ORCID logo ,
Xiaoxiao Deng
,
Yue Chen
,
Xiaohong Hou
,
Qian Wang
,
Zhao Jin
,
Gang Song
,
Jun He
,
Yulong Yin
* ,
Kang Xu
* ORCID logo
Version 1 : Received: 27 July 2023 / Approved: 28 July 2023 / Online: 28 July 2023 (14:07:13 CEST)

A peer-reviewed article of this Preprint also exists.

Zeng, Q.; Gao, H.; Yin, S.; Peng, Y.; Yang, F.; Fu, Y.; Deng, X.; Chen, Y.; Hou, X.; Wang, Q.; Jin, Z.; Song, G.; He, J.; Yin, Y.; Xu, K. Genome-Wide Association Study and Identification of Candidate Genes for Intramuscular Fat Fatty Acid Composition in Ningxiang Pigs. Animals 2023, 13, 3192. Zeng, Q.; Gao, H.; Yin, S.; Peng, Y.; Yang, F.; Fu, Y.; Deng, X.; Chen, Y.; Hou, X.; Wang, Q.; Jin, Z.; Song, G.; He, J.; Yin, Y.; Xu, K. Genome-Wide Association Study and Identification of Candidate Genes for Intramuscular Fat Fatty Acid Composition in Ningxiang Pigs. Animals 2023, 13, 3192.

Abstract

Ningxiang pigs exhibit a diverse array of fatty acids, making them an intriguing model for exploring the genetic underpinnings of Fatty acid metabolism. In this study, we conducted a genome-wide association study using a dataset comprising 50,697 SNPs and samples from over 600 Ningxiang pigs. Our investigation yielded novel candidate genes linked to five saturated fatty acids (SFAs), four monounsaturated fatty acids (MUFAs), and five polyunsaturated fatty acids (PUFAs). Re-markably, 37, 21, and 16 SNPs showed significant associations with SFAs, MUFAs, and PUFAs, respectively. Notably, ALGA0047587, H3GA0046208, DRGA0016063, and ALGA0031262 demonstrated substantial phenotypic variance (≥ 30%) in Arachidic acid (C20:0), Elaidic Acid (C18:1n-9(t)), and Arachidonic acid (C20:4n-6), respectively. Several significant SNPs were posi-tioned proximally to previously reported genes. In total, we identified 11, 6, and 5 candidate genes associated with SFAs, MUFAs, and PUFAs, respectively. These findings hold great promise for advancing breeding strategies aimed at optimizing meat quality and enhancing lipid metabolism within the intramuscular fat (IMF) of Ningxiang pigs.

Keywords

longissimus dorsi; saturated fatty acids; monounsaturated fatty acids; polyunsaturated fatty acid; GWAS

Subject

Biology and Life Sciences, Agricultural Science and Agronomy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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