Syed, S.; Qasim, S.; Ejaz, M.; Sammar; Khan, N.; Ali, H.; Zaker, H.; Hatzidaki, E.; Mamoulakis, C.; Tsatsakis, A.; Shah, S.T.A.; Amir, S. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics2023, 11, 725.
Syed, S.; Qasim, S.; Ejaz, M.; Sammar; Khan, N.; Ali, H.; Zaker, H.; Hatzidaki, E.; Mamoulakis, C.; Tsatsakis, A.; Shah, S.T.A.; Amir, S. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics 2023, 11, 725.
Syed, S.; Qasim, S.; Ejaz, M.; Sammar; Khan, N.; Ali, H.; Zaker, H.; Hatzidaki, E.; Mamoulakis, C.; Tsatsakis, A.; Shah, S.T.A.; Amir, S. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics2023, 11, 725.
Syed, S.; Qasim, S.; Ejaz, M.; Sammar; Khan, N.; Ali, H.; Zaker, H.; Hatzidaki, E.; Mamoulakis, C.; Tsatsakis, A.; Shah, S.T.A.; Amir, S. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics 2023, 11, 725.
Abstract
Persistent Organic Pollutants (POP) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found in detectable amounts in organisms and the environment even after its use was banned in the 1970s. Studies show that exposure to DDT can cause adverse health effects in humans and animals, impairing fertility and increasing the risk of developing cancer. The aim of this work is to provide a comprehensive overview of the available literature on the effect of DDT and its metabolites on female reproductive tract, leading to infertility and cancer. Medline and Google Scholar were systematically searched to detect all relevant animal and human studies published in the last 20 years (January 2003 to February 2023) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. In total, 38 studies were included for qualitative synthesis. This systematic search and review indicated that exposure to DDT is associated with female reproductive health decline and that DDT acts as a sufficient carcinogen instigating reproductive cancers.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.