Stan, M.C.; Georgescu, D.; Mireștean, C.C.; Bădulescu, F. Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome. Diagnostics2023, 13, 2647.
Stan, M.C.; Georgescu, D.; Mireștean, C.C.; Bădulescu, F. Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome. Diagnostics 2023, 13, 2647.
Stan, M.C.; Georgescu, D.; Mireștean, C.C.; Bădulescu, F. Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome. Diagnostics2023, 13, 2647.
Stan, M.C.; Georgescu, D.; Mireștean, C.C.; Bădulescu, F. Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome. Diagnostics 2023, 13, 2647.
Abstract
Abstract: Background and Objectives: A growing number of epidemiologic studies have found that diabetes mellitus may increase cancer risk and is implicated in numerous other metabolic and inflammatory disorders. The increase in pro-inflammatory cytokines plays a major role in insulin resistance and leads to hypoalbuminemia, and micro- and macrovascular diabetes complications, including kidney disease and anemia. This study aimed to investigate the utility of CEA, CRP, serum albumin level, hemoglobin, and LDH as biomarkers for cancer risk and the biological implications of diabetes on the evolution and prognosis of oncological patients. Material and methods: We conducted a retrospective, longitudinal, observational study, on a total group of 434 patients, 217 diagnosed with a form of cancer and with type 2 diabetes as a comorbidity, and the other 217 – control group, without diabetes. These patients were admitted to the oncology clinic. In subgroups, the same number of patients was considered, depending on the location of the oncological pathology. Anemia, hypoalbuminemia, elevated lactate dehydrogenase, glycated hemoglobin, and C-reactive protein levels are more pronounced in subjects with type 2 diabetes and cancer. Conclusions: The presence of diabetes negatively affects the clinical and biological prognosis of cancer patients.
Keywords
diabetes,cancer,anemia,albumin
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
