The Role of Chronic Fatigue in Patients with Crohn’s Disease

Marcin Włodarczyk; Adam Makaro; Mateusz Prusisz; Jakub Włodarczyk; Marta Nowocień; Kasper Maryńczak; Jakub Fichna; Łukasz Dziki

doi:10.20944/preprints202307.1105.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202307.1105.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Chronic Fatigue in Patients with Crohn’s Disease

^* ,

Version 1 : Received: 17 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (10:47:41 CEST)

A peer-reviewed article of this Preprint also exists.

Włodarczyk, M.; Makaro, A.; Prusisz, M.; Włodarczyk, J.; Nowocień, M.; Maryńczak, K.; Fichna, J.; Dziki, Ł. The Role of Chronic Fatigue in Patients with Crohn’s Disease. Life 2023, 13, 1692. Włodarczyk, M.; Makaro, A.; Prusisz, M.; Włodarczyk, J.; Nowocień, M.; Maryńczak, K.; Fichna, J.; Dziki, Ł. The Role of Chronic Fatigue in Patients with Crohn’s Disease. Life 2023, 13, 1692.

Abstract

Crohn's disease (CD) is a chronic, relapsing disorder belonging to inflammatory bowel diseases (IBD). It is manifested by relapsing transmural inflammation found in any segment of the gastrointestinal tract. Chronic fatigue is a common and underrecognized symptom of CD, which prevalence is much higher in the population of CD patients as compared to healthy population. It stems from an intricate web of interactions between various risk factors, and its pathophysiology is still not fully understood. Implementation of routine screening and holistic, multidisciplinary approach involving psychological support may be crucial in management of CD patients with chronic fatigue. There is currently no single intervention aimed at decreasing fatigue alone, and its treatment is especially difficult in patients with fatigue persisting despite clinical and endoscopic remission. Extensive research is still needed in order to be able to predict, prevent, identify and ultimately treat fatigue associated with CD. The aim of this review is to summarize the knowledge on the etiology, diagnosis, and treatment of chronic fatigue in CD patients.

Keywords

Crohn’s disease; fatigue; pathophysiology; chronic fatigue syndrome

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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