Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma

Valentina Giansante
,
Gianmarco Stati
ORCID logo ,
Silvia Sancilio
,
Emanuela Guerra
ORCID logo ,
Saverio Alberti
,
Roberta Di Pietro
* ORCID logo
Version 1 : Received: 13 July 2023 / Approved: 13 July 2023 / Online: 14 July 2023 (09:07:24 CEST)

A peer-reviewed article of this Preprint also exists.

Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2023, 24, 12633. Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2023, 24, 12633.

Abstract

Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has con-tinued to increase by about 1% each year in both men and women. Although the 5‐year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strate-gies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression.

Keywords

pancreatic cancer; necroptosis; tumor microenvironment; cell death

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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