Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Periodontal Diseases

Giuseppe Giannini; Irene Ragusa; Giulia Nerina Nardone; Sara Soldi; Marina Elli; Piera Valenti; Luigi Rosa

doi:10.20944/preprints202307.0622.v1

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preprints.org > medicine and pharmacology > dentistry and oral surgery > doi: 10.20944/preprints202307.0622.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Periodontal Diseases

Giuseppe Giannini

^* ,

Irene Ragusa

Giulia Nerina Nardone

Version 1 : Received: 9 July 2023 / Approved: 10 July 2023 / Online: 10 July 2023 (11:34:50 CEST)

A peer-reviewed article of this Preprint also exists.

Giannini, G.; Ragusa, I.; Nardone, G.N.; Soldi, S.; Elli, M.; Valenti, P.; Rosa, L. Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases. Gels 2023, 9, 607. Giannini, G.; Ragusa, I.; Nardone, G.N.; Soldi, S.; Elli, M.; Valenti, P.; Rosa, L. Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases. Gels 2023, 9, 607.

Abstract

: An innovative and stable probiotics-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated with periodontal diseases. Tau-Marin gel was tested against some pathogenic bacteria, belonging to the so-called "red complex", recognized as the most important pathogens in plaque specimens, adherent to the epithelial lining of periodontal pockets. A detailed physico-chemical profile of AL0020 and its in vitro efficacy in protecting activity against pathogenic bacteria as well as soothing or irritative effect on gingival epithelium were reported. Moreover, a clinical-dermatological trial on 20 volunteers using the product once a day for 30 days was also performed.

Keywords

Tau-Marin; Mucoadhesive gel; oral formulation; probiotics; periodontitis; periodontal diseases; slow delivery

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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