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Version 1
Preserved in Portico This version is not peer-reviewed
Analysis of Tianeptine in Dietary Supplements
Version 1
: Received: 4 July 2023 / Approved: 5 July 2023 / Online: 5 July 2023 (13:04:28 CEST)
A peer-reviewed article of this Preprint also exists.
Seale, J.T.; Garden, E.A.; French, J.M.T.; McDougal, O.M. Analysis of Tianeptine in Dietary Supplements. Nutraceuticals 2023, 3, 481-488. Seale, J.T.; Garden, E.A.; French, J.M.T.; McDougal, O.M. Analysis of Tianeptine in Dietary Supplements. Nutraceuticals 2023, 3, 481-488.
Abstract
In the United States (US), tianeptine is sold as a dietary supplement under the trade name Tianaa™. Tianeptine is a synthetic drug prescribed by physicians as an antidepressant in parts of Europe, Asia and South America. The drug is not permitted for use by physicians in the US, be-cause it is a μ-opioid receptor agonist with a propensity for severe addiction. As incidence of Tianaa™ related opioid addiction across the southern US escalate, the current study aimed to quantify tianeptine in over the counter Tianaa™ White, Red, and Green products. The results of this investigation measured tianeptine levels between 3.1 to 10.9 mg per 531 mg capsules. Tianaa™ White capsules consistently contained the least tianeptine, while Green had the most. Close inspection of Tianaa™ products showed that capsule mass varied by as much as 16% from label claim, and the amount of tianeptine per capsule varied by as much as 35 % from the aver-age measured amount for each product. Tianaa™ Red contains kava leaf extract, which led to the identification of four kavapyrone components by mass spectrometry. The data presented pro-vide insight into tianeptine quantity and capsule mass variation for Tianaa™ supplements sold to customers naive to the risk of addiction.
Keywords
Dietary supplement, μ-opioid-receptor agonist, addiction, antidepressant
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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