Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Lymphadenectomy in Early-Stage NSCLC

Beatrice Manfredini
* ORCID logo ,
Carmelina Cristina Zirafa
* ORCID logo ,
Pier Luigi Filosso
,
Alessandro Stefani
,
Gaetano Romano
ORCID logo ,
Federico Davini
,
Franca Melfi
Version 1 : Received: 4 July 2023 / Approved: 4 July 2023 / Online: 5 July 2023 (08:40:07 CEST)

A peer-reviewed article of this Preprint also exists.

Manfredini, B.; Zirafa, C.C.; Filosso, P.L.; Stefani, A.; Romano, G.; Davini, F.; Melfi, F. The Role of Lymphadenectomy in Early-Stage NSCLC. Cancers 2023, 15, 3735. Manfredini, B.; Zirafa, C.C.; Filosso, P.L.; Stefani, A.; Romano, G.; Davini, F.; Melfi, F. The Role of Lymphadenectomy in Early-Stage NSCLC. Cancers 2023, 15, 3735.

Abstract

Lung cancer remains the leading cause of cancer-related death worldwide. The involvement of lymph nodes by the tumor has a strong impact on survival of patients. For this reason, lymphadenectomy plays a crucial role in the staging and prognosis of NSCLC, to define the most appropriate therapeutic strategies concerning the stage of the disease. To date, the benefit, in terms of survival, of the different extents of lymphadenectomy remains controversial in the scientific community. It is recognized that metastatic involvement of mediastinal lymph nodes in lung cancer is one of the most significant prognostic factors, in terms of survival, and it is therefore mandatory to identify patients with lymph node metastases who may benefit from adjuvant therapies, to prevent distant disease and local recurrences. The purpose of this review is to evaluate, the role of lymphadenectomy in early-stage NSCLC in terms of efficacy and accuracy, comparing systematic, sampling and lobe-specific lymph node dissection and analyzing the existing critical issue, through a search of the most relevant articles published in the last decades.

Keywords

early-stage; stage I; NSCLC; Lymphadenectomy; Micrometastases

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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