Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering

Dennis Douroumis
* ORCID logo ,
Atabak Ghanizadeh Tabriz
,
Quentin Gonot-Munck
,
Arnaud Baudoux
,
Vivek Garg
,
Richard Farnish
,
Orestis Katsamenis
,
Hui Ho-Wah
,
Nathan Boersen
,
Sandra Roberts
,
John Jones
Version 1 : Received: 3 July 2023 / Approved: 4 July 2023 / Online: 5 July 2023 (02:21:40 CEST)

A peer-reviewed article of this Preprint also exists.

Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics 2023, 15, 2230. Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics 2023, 15, 2230.

Abstract

Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dos-age forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25 and 12.5 mg. The tuning of the SLS processing parameter laser intensity, improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug re-leased. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet po-rosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.

Keywords

3D printing; selective laser sintering; personalised medicines; oral; carvedilol

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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