Alva-Chavarría, D.; Soto-Núñez, M.; Flores-Soto, E.; Jaimez, R. Hemostatic Effects of Raloxifene in Ovariectomized Rats. Life2023, 13, 1612.
Alva-Chavarría, D.; Soto-Núñez, M.; Flores-Soto, E.; Jaimez, R. Hemostatic Effects of Raloxifene in Ovariectomized Rats. Life 2023, 13, 1612.
Alva-Chavarría, D.; Soto-Núñez, M.; Flores-Soto, E.; Jaimez, R. Hemostatic Effects of Raloxifene in Ovariectomized Rats. Life2023, 13, 1612.
Alva-Chavarría, D.; Soto-Núñez, M.; Flores-Soto, E.; Jaimez, R. Hemostatic Effects of Raloxifene in Ovariectomized Rats. Life 2023, 13, 1612.
Abstract
This study aimed to explore the effects of raloxifene (Rx) and estradiol (E2) on prothrombin time (PT), partial thromboplastin time (APTT), coagulation factors (VII, X, XI), and fibrinogen concen-trations in rats. Rats were ovariectomized 11 days prior to starting the treatment. Then they re-ceived Rx or E2 (1 to 1000 µg/Kg) or propylene glycol (0.3 ml; vehicle, V) subcutaneously for three consecutive days. Plasmas were collected to measure the hemostatic parameters. Rx significantly increased PT (8%, at 1000 µg/Kg; p<0.05) and APTT at all doses evaluated (32, 70, 67, 30%; p<0.05, respectively). Rx (1 to 1000 µg/Kg) decreased the activity of factor VII by -20, -40, -37, and -17% (p<0.05), respectively, while E2 increased it by 9, 34, 52, and 29%; Rx reduced factor X activity at 10 and 100 µg/kg doses (-30, and -30% p<0.05), while E2 showed an increment of 24% with 1000 µg/kg dose only; Rx (1-100 µg/Kg) diminished FXI activity (-71, -62, -66; p<0.05), while E2 (1 and 10 µg/Kg) diminished it in -60 and -38, respectively (p<0.05); Rx (1000 µg/Kg) produced an increment of 29% (p<0.05) in fibrinogen concentration, but not E2. Our findings suggest that raloxifene has a pro-tective effect on hemostasis in rats.
Medicine and Pharmacology, Medicine and Pharmacology
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