Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

The Homoleptic Curcumin-Copper Single Crystal (ML2): A Long Awaited Cherry on the Cake in the Field of Curcumin Metal Complexes

Antonino Arenaza Corona
,
Marco A. Obregón Mendoza
ORCID logo ,
William Meza Morales
,
María Teresa Ramírez Apan
,
Antonio Nieto Camacho
ORCID logo ,
Rubén A. Toscano
ORCID logo ,
Leidys L. Pérez González
,
Rubén Sánchez Obregón
,
Raúl G. Enríquez
* ORCID logo
Version 1 : Received: 28 June 2023 / Approved: 29 June 2023 / Online: 29 June 2023 (13:26:13 CEST)

A peer-reviewed article of this Preprint also exists.

Arenaza-Corona, A.; Obregón-Mendoza, M.A.; Meza-Morales, W.; Ramírez-Apan, M.T.; Nieto-Camacho, A.; Toscano, R.A.; Pérez-González, L.L.; Sánchez-Obregón, R.; Enríquez, R.G. The Homoleptic Curcumin–Copper Single Crystal (ML2): A Long Awaited Breakthrough in the Field of Curcumin Metal Complexes. Molecules 2023, 28, 6033. Arenaza-Corona, A.; Obregón-Mendoza, M.A.; Meza-Morales, W.; Ramírez-Apan, M.T.; Nieto-Camacho, A.; Toscano, R.A.; Pérez-González, L.L.; Sánchez-Obregón, R.; Enríquez, R.G. The Homoleptic Curcumin–Copper Single Crystal (ML2): A Long Awaited Breakthrough in the Field of Curcumin Metal Complexes. Molecules 2023, 28, 6033.

Abstract

The first single crystal structure of the homoleptic copper (II) ML2 complex (M=Cu (II), L=curcumin) was obtained and its structure was elucidated by X-ray diffraction showing a square planar geometry. The supramolecular arrangement is supported by C-H···O interactions and the solvent (MeOH) plays an important role in stabilizing the crystal packing. The cytotoxic activity of the complex against six cancer cell lines substantially surpasses that of curcumin itself, and it is particularly selective against leukemia (K562) and human glioblastoma (U251) cell lines with similar antioxidant activity to BHT. This constitutes the first crystal structure of pristine curcumin complexed with a metal ion.

Keywords

Curcumin-Copper (II); single crystal; cytotoxicity; antioxidant

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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