Srivastava, A.; Srivastava, A.; Singh, R.K. Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus. Int. J. Mol. Sci.2023, 24, 14955.
Srivastava, A.; Srivastava, A.; Singh, R.K. Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus. Int. J. Mol. Sci. 2023, 24, 14955.
Srivastava, A.; Srivastava, A.; Singh, R.K. Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus. Int. J. Mol. Sci.2023, 24, 14955.
Srivastava, A.; Srivastava, A.; Singh, R.K. Insight into the Epigenetics of Kaposi’s Sarcoma-Associated Herpesvirus. Int. J. Mol. Sci. 2023, 24, 14955.
Abstract
Epigenetic reprogramming represents a series of essential events during many cellular processes including oncogenesis. Genome of Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic herpesvirus is predetermined for a well-orchestrated epigenetic reprogramming once it enters into a host cell. The initial epigenetic reprogramming of KSHV genome allow restricted expression of encoded genes and helps to hide from host immune recognition. The infection with KSHV is associated with Kaposi's Sarcoma, Multicentric Castleman's disease, KSHV inflammatory cytokine syndrome and primary effusion lymphoma. The major epigenetic modifications associated with KSHV can be labelled under three broad categories: DNA methylation, modifications of Histone, and the role of noncoding RNAs. These epigenetic modifications significantly contribute towards the latent-lytic switch of the KSHV lifecycle. This review gives a brief account of the major epigenetic modifications affiliated with the KSHV genome in infected cells and their impact on pathogenesis.
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