PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.
Version 1
: Received: 24 June 2023 / Approved: 25 June 2023 / Online: 25 June 2023 (08:26:05 CEST)
How to cite:
Yu, N.; Wang, J.; Liu, Y.; Guo, Y. Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.. Preprints2023, 2023061726. https://doi.org/10.20944/preprints202306.1726.v1
Yu, N.; Wang, J.; Liu, Y.; Guo, Y. Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.. Preprints 2023, 2023061726. https://doi.org/10.20944/preprints202306.1726.v1
Yu, N.; Wang, J.; Liu, Y.; Guo, Y. Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.. Preprints2023, 2023061726. https://doi.org/10.20944/preprints202306.1726.v1
APA Style
Yu, N., Wang, J., Liu, Y., & Guo, Y. (2023). Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study.. Preprints. https://doi.org/10.20944/preprints202306.1726.v1
Chicago/Turabian Style
Yu, N., Yuancheng Liu and Yeye Guo. 2023 "Investigating the Causal Relationship of Gut Microbiota with Psoriasis and Psoriatic Arthritis: A Bidirectional Two-Sample Mendelian Randomization Study." Preprints. https://doi.org/10.20944/preprints202306.1726.v1
Abstract
Background: Numerous investigations have shed light on the intriguing interplay between gut microbiota(GM) and psoriasis (Ps) as well as psoriatic arthritis (PsA). However, the precise nature of the causal relationship between them remains an area of active investigation.
Methods: For the purpose of our investigation, we meticulously curated a collection of genetic variants (P < 1 × 10−5) associated with GM (n = 18,340) derived from the MiBioGen study. To explore the intricate relationship between GM and Ps as well as PsA, we harnessed the comprehensive resources of the FinnGen database, encompassing a vast cohort of individuals, including 4,510 Ps cases and 212,242 controls, and 1,637 PsA cases and 212,242 controls. Even complementary MR methods were implemented, including an inverse variance weighting method, followed by a sensitivity analysis to verify the robustness of the results.
Results: In this study, we found that certain bacterial taxa, such as Lactococcus, Ruminiclostridium 5, and Eubacterium fissicatena, were identified as risk factors. Conversely, Alloprevotella and Odoribacter demonstrated a protective effect against Ps. In the case of PsA, our results revealed a distinct set of risk factors and protective factors among the gut bacterial taxa. Lactococcus, Verrucomicrobiales, Akkermansia, Coprococcus 1, Lachnospiraceae, and Verrucomicrobiaceae were identified as risk factors for PsA. On the other hand, Odoribacter, Rikenellaceae, Clostridium innocuum, and Marvinbryantia exhibited a protective effect against the development of PsA.
Conclusion: Our findings shed light on the distinctive disease characteristics and onset features between Ps and PsA. Notably, certain intestinal flora were implicated in the pathogenesis of PsA, suggesting their potential role as early diagnostic indicators. Furthermore, we identified several bacterial flora that exhibit a potential protective effect against the occurrence of Ps and PsA. These discoveries lay a solid foundation for future endeavors in the prevention and treatment of these conditions.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
