Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients With Mild Cognitive Impairment

Yeo Jin Kim
ORCID logo ,
Ingyu Park
,
Hui-Chul Choi
,
Moo-Eob Ahn
,
Ohk-Hyun Ryu
ORCID logo ,
Daehun Jang
,
Unjoo Lee
* ,
Sang-Kyu Lee
* ORCID logo
Version 1 : Received: 16 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (09:00:08 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, Y.J.; Park, I.; Choi, H.-C.; Ahn, M.-E.; Ryu, O.-H.; Jang, D.; Lee, U.; Lee, S.-K. Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment. J. Clin. Med. 2023, 12, 5347. Kim, Y.J.; Park, I.; Choi, H.-C.; Ahn, M.-E.; Ryu, O.-H.; Jang, D.; Lee, U.; Lee, S.-K. Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment. J. Clin. Med. 2023, 12, 5347.

Abstract

Background Some patients with mild cognitive impairment (MCI) experience gait disturbances. However, there are few reports on the relationship between gait disturbance and cognitive function in patients with MCI. Therefore, we investigated the neural correlates of gait characteristics related to cognitive dysfunction. Methods Eighty patients diagnosed with MCI from three dementia centres in Gangwon-do, Korea were recruited for this study. We defined MCI as a Clinical Dementia Rating global score of 0.5 or higher, with a memory domain score of 0.5 or greater. The patients were classified as having either early or late MCI based on their Mini Mental Status Examination z-scores. Multiple logistic regression analysis was performed to examine the association between the gait characteristics and cognitive impairment. Analyses included variables such as age, sex, years of education, number of comorbidities, body mass index and height. Results Gait velocity, step count, step length, heel-to-heel base support, swing and stance phase duration, and support time were associated with cognitive function. A decrease in gray matter volume in the right pericalcarine area was associated with gait characteristics related to cognitive dysfunction. An increase in the curvature of gray matter in the right entorhinal, right lateral orbitofrontal, right cuneus, and right and left pars opercularis areas was also associated with gait characteristics related to cognitive dysfunction. Conclusion Since gait impairment is an important factor in determining activities of daily living in patients with mild cognitive impairment, the evaluation of gait and cognitive functions in patients with mild cognitive impairment is important.

Keywords

gait; cognitive function; mild cognitive impairment; neural correlates

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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