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Pectoralis Major in Salvage Total Laryngectomy After Irradiation. Morbidity, Mortality, Functional and Oncological Results in a Referral Center in Egypt
Abdelghany, M.; Amin, A.; Degni, E.; Crescio, C.; Hassan, A.E.M.A.; Ftohy, T.; Bussu, F. Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt. J. Pers. Med.2023, 13, 1223.
Abdelghany, M.; Amin, A.; Degni, E.; Crescio, C.; Hassan, A.E.M.A.; Ftohy, T.; Bussu, F. Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt. J. Pers. Med. 2023, 13, 1223.
Abdelghany, M.; Amin, A.; Degni, E.; Crescio, C.; Hassan, A.E.M.A.; Ftohy, T.; Bussu, F. Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt. J. Pers. Med.2023, 13, 1223.
Abdelghany, M.; Amin, A.; Degni, E.; Crescio, C.; Hassan, A.E.M.A.; Ftohy, T.; Bussu, F. Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt. J. Pers. Med. 2023, 13, 1223.
Abstract
Background: Non-surgical organ preservation protocols have known a large diffusion worldwide in the last decades. Their oncological and functional effectiveness in a real-world setting has been recently ques-tioned, also because of the high morbidity of salvage procedures. The aim of this study is to review the outcomes of post irradiation salvage total laryngectomy (STL) and reconstruction with pectoralis major flap. Methods: This retrospective observational study included 37 cases of STL in the period going from January 2015 to December 2021. Data for each patient were extracted from the hospital information system and reviewed. Results: The 3-year overall and disease specific survival are respectively 28% and 51%. All patients with recurrences died from the disease. Only 7 recurrences and 7 consequent deaths for cancer were rec-orded. The other 14 deaths derived from comorbidities, being diabetes the most significant predictive parameter for overall survival. Also low-er postoperative albumin levels were associated with a higher risk of death. Conclusions: Overall survival after STL and reconstruction with PMMF is low but most deaths are due to comorbidities and not to cancer progression or recurrence.
Keywords
salvage total laryngectomy; radiotherapy; pectoralis major flap; pharyngocutaneous fistula; laryngeal cancer; surgical morbidity; organ preservation
Subject
Medicine and Pharmacology, Otolaryngology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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