Version 1
: Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (09:10:18 CEST)
How to cite:
Da Silva, B. C. M.; Da Silva, L. T.; Hildebrando, G. F.; Rigato, P. O.; Brigido, L. F. D. M.; Magri, M. M. C.; Monteiro, M. A.; Assone, T.; Duarte, A. J. D. S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1
Da Silva, B. C. M.; Da Silva, L. T.; Hildebrando, G. F.; Rigato, P. O.; Brigido, L. F. D. M.; Magri, M. M. C.; Monteiro, M. A.; Assone, T.; Duarte, A. J. D. S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints 2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1
Da Silva, B. C. M.; Da Silva, L. T.; Hildebrando, G. F.; Rigato, P. O.; Brigido, L. F. D. M.; Magri, M. M. C.; Monteiro, M. A.; Assone, T.; Duarte, A. J. D. S.; Casseb, J. People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints2023, 2023060286. https://doi.org/10.20944/preprints202306.0286.v1
APA Style
Da Silva, B. C. M., Da Silva, L. T., Hildebrando, G. F., Rigato, P. O., Brigido, L. F. D. M., Magri, M. M. C., Monteiro, M. A., Assone, T., Duarte, A. J. D. S., & Casseb, J. (2023). People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope. Preprints. https://doi.org/10.20944/preprints202306.0286.v1
Chicago/Turabian Style
Da Silva, B. C. M., Alberto José da Silva Duarte and Jorge Casseb. 2023 "People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope" Preprints. https://doi.org/10.20944/preprints202306.0286.v1
Abstract
We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T cell, viral load, HIV-1 genotype, class I HLA genotype, CCR5 polymorphism, and IFN-γ producing cells from a cohort of 37 people living with HIV-1 (PLWH) (viremic controllers, were compared those on antiretroviral therapy (ART) from two sites in São Paulo, Brazil. Half the PLWH (51.4%) were classified as viremic controllers (Controller group - CG), compared to 48.6% were on ART. As expected, controllers showed baseline higher levels of CD4+ T cells and nadir compared to those under ART, confirming the ability of HIV-1 controllers to preserve these cells even in the absence of ART. IFN-γ-producing cells showed greater magnitude to the HIV peptides Gag in controllers (p<0.03). Our results demonstrated that HLA protective alleles are associated with strong production of IFN-γ to Gag, Nef and RT epitopes in people living with HIV controllers.
Keywords
Human Immunodeficiency Virus (HIV); Long-Term Non-Progressor (LTNP), Elite Controllers (EC); Viremic Controllers (VC); IFN-γ T cell responses; Human Leukocyte Antigens (HLA)
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.