Version 1
: Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (10:40:16 CEST)
How to cite:
Sardelli, L.; Boeri, L.; Guagliano, G.; Merli, M.; Vangosa, F.B.; Petrini, P. Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel Diseases. Preprints2023, 2023052116. https://doi.org/10.20944/preprints202305.2116.v1
Sardelli, L.; Boeri, L.; Guagliano, G.; Merli, M.; Vangosa, F.B.; Petrini, P. Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel Diseases. Preprints 2023, 2023052116. https://doi.org/10.20944/preprints202305.2116.v1
Sardelli, L.; Boeri, L.; Guagliano, G.; Merli, M.; Vangosa, F.B.; Petrini, P. Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel Diseases. Preprints2023, 2023052116. https://doi.org/10.20944/preprints202305.2116.v1
APA Style
Sardelli, L., Boeri, L., Guagliano, G., Merli, M., Vangosa, F.B., & Petrini, P. (2023). Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel Diseases. Preprints. https://doi.org/10.20944/preprints202305.2116.v1
Chicago/Turabian Style
Sardelli, L., Francesco Briatico Vangosa and Paola Petrini. 2023 "Mucus Perspective to Conduct the Molecular Concertation in Inflammatory Bowel Diseases" Preprints. https://doi.org/10.20944/preprints202305.2116.v1
Abstract
The inflammatory bowels diseases (IBD) are autoimmune diseases that deeply impact the patients’ quality of life. The IBD pathogenesis is not yet defined, but evidence demonstrated that the IBD chronic inflammation is related to an impaired intestinal barrier. Traditionally, two actors were considered for their contribution to this disfunction: the gut microbiota and intestinal epithelium. However, a third element, which is the intestinal mucus, should be considered as peer of the epithelium and microbiota. Indeed, mucus represents the biological interface between bacteria and cells, filtering molecules or toxins and preventing bacteria penetration exploiting both structural and compositional properties. The boosting effect of the mucus characterization towards IBD comprehension is far too underestimated, although some mucus-oriented studies are already reported in literature. This work reviews the intestinal barrier features, describing each component of the gut mucosa (i.e., epithelium, microbiota, and mucus) in a mucus-oriented perspective.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.