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Haemodynamic Effects of Pimobendan During General Anaesthesia in Healthy Senior Dogs: A Prospective, Randomised, Triple-Blinded, Placebo-Controlled Clinical Study
Sández, I.; Redondo, J.I.; Donati, P.A.; Gómez, J. Haemodynamic Effects of Pimobendan during General Anaesthesia in Healthy Senior Dogs: A Prospective, Randomised, Triple-Blinded, Placebo-Controlled Clinical Study. Animals2023, 13, 2110.
Sández, I.; Redondo, J.I.; Donati, P.A.; Gómez, J. Haemodynamic Effects of Pimobendan during General Anaesthesia in Healthy Senior Dogs: A Prospective, Randomised, Triple-Blinded, Placebo-Controlled Clinical Study. Animals 2023, 13, 2110.
Sández, I.; Redondo, J.I.; Donati, P.A.; Gómez, J. Haemodynamic Effects of Pimobendan during General Anaesthesia in Healthy Senior Dogs: A Prospective, Randomised, Triple-Blinded, Placebo-Controlled Clinical Study. Animals2023, 13, 2110.
Sández, I.; Redondo, J.I.; Donati, P.A.; Gómez, J. Haemodynamic Effects of Pimobendan during General Anaesthesia in Healthy Senior Dogs: A Prospective, Randomised, Triple-Blinded, Placebo-Controlled Clinical Study. Animals 2023, 13, 2110.
Abstract
Pimobendan is an inotropic and vasodilator drug with no sympathomimetic effects. This study aimed to evaluate the haemodynamic effects of pimobendan during anaesthesia in healthy senior dogs. A prospective, randomised, triple-blinded, placebo-controlled clinical study was conducted. Thirty-three dogs (median [range]: 9 [7, 12] years) were anaesthetised for surgical procedures. Dogs were randomly allocated into two groups: eighteen dogs received pimobendan 0.15 mg kg-1 IV (PIMOBENDAN) and 15, saline solutions 0.2 ml kg-1 IV (PLACEBO). Data were recorded before, 1 minute, 10 minutes and 20 minutes after injection. Velocity-time integral (VTI), peak-velocity (PV) and mean-acceleration (MA) were measured using an oesophageal Doppler monitor (ODM). Heart rate and mean arterial pressure were also registered. Data were analysed using a two-way ANOVA for trimmed means. Statistical differences were considered if p < 0.05. Twenty minutes after injection, VTI (13.0 cm [10.4, 22.3]), PV (95.0 [83.0, 160] m sec-1), and MA (12.6 [9.40, 17.0] m sec-2) were higher in PIMOBENDAN when compared to PLACEBO (VTI: 10.5 [6.50, 17.4] cm, PV: 80.0 [62.0, 103] m sec-1 and MA: 10.2 [7.00, 16.0] m sec-2). No differences were observed in the rest of the variables. Using pimobendan during anaesthesia increases VTI, PV and MA measured by an ODM.
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