Meng, Q.; Tong, S.; Zhao, Y.; Peng, X.; Li, Z.; Feng, T.; Liu, J. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition. Molecules2023, 28, 4590.
Meng, Q.; Tong, S.; Zhao, Y.; Peng, X.; Li, Z.; Feng, T.; Liu, J. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition. Molecules 2023, 28, 4590.
Meng, Q.; Tong, S.; Zhao, Y.; Peng, X.; Li, Z.; Feng, T.; Liu, J. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition. Molecules2023, 28, 4590.
Meng, Q.; Tong, S.; Zhao, Y.; Peng, X.; Li, Z.; Feng, T.; Liu, J. New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition. Molecules 2023, 28, 4590.
Abstract
The Paeonia suffruticosa, called as 'Feng Dan', has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely paeobenzofuranone A‒E (1‒5), have been characterized. Their structures were determined by spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds 2, 4, and 5 showed cytotoxicity against three human cancer cell lines with IC50 values ranging from 6.7 to 25.1 μM. Compounds 1 and 2 showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of P. suffruticosa are reported for the first time.
Keywords
Paeonia suffruticosa; benzofuranones; cytotoxicity; NO production inhibition
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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