Dinatolo, M.F.; Pur, D.R.; Eagleson, R.; de Ribaupierre, S. The Role of Blood Oxygen Level Dependent Signal Variability in Pediatric Neuroscience: A Systematic Review. Life2023, 13, 1587.
Dinatolo, M.F.; Pur, D.R.; Eagleson, R.; de Ribaupierre, S. The Role of Blood Oxygen Level Dependent Signal Variability in Pediatric Neuroscience: A Systematic Review. Life 2023, 13, 1587.
Dinatolo, M.F.; Pur, D.R.; Eagleson, R.; de Ribaupierre, S. The Role of Blood Oxygen Level Dependent Signal Variability in Pediatric Neuroscience: A Systematic Review. Life2023, 13, 1587.
Dinatolo, M.F.; Pur, D.R.; Eagleson, R.; de Ribaupierre, S. The Role of Blood Oxygen Level Dependent Signal Variability in Pediatric Neuroscience: A Systematic Review. Life 2023, 13, 1587.
Abstract
Background: As pediatric BOLD SV is relatively novel, there is a need to provide a foundational framework that gives researchers an entry point into engaging with the topic. This begins with clarifying the definition of BOLD variability by identifying and categorizing the various metrics utilized to measure BOLD SV; Methods: A systematic review of the literature was conducted. Inclusion criteria were restricted to studies utilizing any metric of BOLD signal variability (BOLD SV) and with individuals younger than 18 in the study population. The definition of BOLD SV was any measure of intra-individual variability in the BOLD signal. Five databases were searched: Psychinfo, Healthstar, Medline, Embase, and Scopus; Results: Seventeen observational studies, including male (n =1796) and female (n =1324) pediatric participants were included. Eight studies quantified variability as the amount of deviation from average BOLD signal, 7 used complexity-based metrics, 3 used correlation measures of variability, and 1 used structure of the hemodynamic response function. Ten methods of quantifying signal variability were identified. Associations and trends in BOLD SV were commonly found with age, factors specific to mental and/or neurological disorders like attention deficit disorder, epilepsy, psychotic symptoms, and performance on psychological and behavioral tasks. Conclusions: BOLD SV is a potential biomarker of neurodevelopmental and neurological conditions and symptom severity in mental disorders for defined pediatric populations. Studies that establish clinical trends and identify the mechanisms underlying BOLD SV with a low risk of bias are needed before clinical applications can be utilized by physicians
Keywords
BOLD Signal Variability; Pediatrics; Biomarker; fMRI; Neurodevelopment
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
